Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Knockin mice"”.
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Mutation of SLC7A14 Causes Syndromic Hearing Loss
… thresholds were elevated in Slc7a14-knockout mice, indicative of progressive hearing loss. However, distortion product otoacoustic emission (DPOAE) measurements showed normal OHC function in wildtype and knockout mice. To confirm syndromic disease, alteration in auditory functions were …
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The Impact of Impaired Cyclooxygenase-2 Activity on Mouse Brain Development: A Focus on Sex Differences
… drugs. Using cyclooxygenase-2 (COX-2) knockin and COX-2 knockout mice, genetic models which mimic exposure to antipyretic drugs, impaired COX-2 activity was found to induce sex-dependent changes in the expression of various neuroimmune markers in the brain during development. Further …
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Defining Ankyrin-b Syndrome: Characterization of Ankyrin-b Variants in Mice and Men and the Discovery of a Role for Ankyrin-b in Parasympathetic Control of Insulin Release
… and reduced InsP3R stability. Ankyrin-B(+/-) mice also display postprandial hyperglycemia, consistent with impaired parasympathetic potentiation of glucose-stimulated insulin secretion. R1788W mutation of ankyrin-B impairs its function in pancreatic islets and associates with type 2 diabetes …
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Deficient experience-dependent plasticity in the visual cortex of Arc null mice
… visual cortical plasticity we took advantage of knockin mice expressing GFP in place of Arc protein (referred to as KO mice for simplicity). We combined intrinsic signal imaging, visually evoked potentials, and two-photon in vivo calcium imaging to assess plasticity in juvenile and adult …
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Why do allelic variants of the mitochondrial chaperone SCO1 cause clinically heterogeneous forms of disease? A mouse model and proximity ligation study
… created and phenotyped three whole body Sco1 knockin mouse models harbouring one or two alleles of the murine equivalent of the pathogenic SCO1 P174L, SCO1 G132S and SCO1 M294V alleles, and characterized the wild-type and mutant SCO1 interactomes in a human cell culture model to identify …
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Harnessing synergy between BCL6 and PI3Kδ to generate a new mouse model for lymphoma
… studied mouse model of DLBCL was generated by knocking a BCL6 transgene into the Igμ locus (μHABCL-6Tg). Our lab has generated a mouse model of APDS in which a hyperactivated PI3Kδ (p110δE1020K) was knocked in constitutively or selectively in B cells or T cells. We crossed p110δE1020K …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… control lymphocyte functions. We use two novel knockin mouse lines developed by the Cantrell laboratory that contain LoxP flanked Foxo1-GFP and Foxo3-GFP reporter genes in the endogenous loci. This gave us the unique opportunity to accurately quantify and compare FOXO1 and FOXO3 expression and …
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The Ontogeny of Vaccine-Induced HIV-1 Glycan-Reactive Antibodies
… ancestor antibody; i.e. the B cells in these mice bear the CH01 antibody heavy and light chain sequences that were predicted to be germline-encoded prior to somatic hypermutation (germline-reverted). With a long HCDR3 of 24 amino acids, B cells bearing the germline-reverted CH01 heavy and …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… were recapitulated in Snord46G11A/G11A knockin mice, in which a single nucleotide mutation dramatically enhances SNORD46-IL-15 binding affinity and drives spontaneous obesity. Critically, CAR-NK cell therapy that was effective under lean conditions lost efficacy against colorectal and …