Global ETD Search

Explorations into protein structure with the knob-socket model

Fraga, Keith Jeffrey2018

… packing of amino acid side-chains. The knob-socket model attempts to organize side-chain packing into tetrahedral packing motifs. This tetrahedral motif is characterized with a three residues on the same secondary structure forming the base of the tetrahedron packing with a side-chain …

u-pacific Repository record for Explorations into protein structure with the knob-socket model (opens in a new tab)

The Rational Investigation of Anti-Cancer Peptide Specificity using the Knob-Socket Model

Patel, Shivarni

u-pacific Repository record for The Rational Investigation of Anti-Cancer Peptide Specificity using the Knob-Socket Model (opens in a new tab)

RATIONAL DESIGN OF PEPTIDES BINDING TOWARDS HUMAN PD-L1 USING KNOB-SOCKET MODEL

Zha, Xingchen

u-pacific Repository record for RATIONAL DESIGN OF PEPTIDES BINDING TOWARDS HUMAN PD-L1 USING KNOB-SOCKET MODEL (opens in a new tab)

Investigating protein folding by the de novo design of an α-helix oligomer

Phan, Jamie2013

… using protein design. The model defines the knob-socket construct as the fundamental unit of packing within protein structure. The knob-socket model characterizes packing specificity in terms of amino acid preferences for sockets in different environments: sockets filled with a knob are …

u-pacific Repository record for Investigating protein folding by the de novo design of an α-helix oligomer (opens in a new tab)

The structural characterization of the Saccharomyces cerevisiae alpha mating factor secretion signal for recombinant protein secretion in Pichia pastoris

Wei, Peter2018

… the secretion signal leader. Based on the knob-socket model and Jpred3 ( a secondary structure predictor), eleven deletions of MAT α prepro secretion signal and one MAT α pre double pro-peptide mutant was engineered and assayed with either horseradish peroxidase (HRP), or Candida antarctica …

u-pacific Repository record for The structural characterization of the Saccharomyces cerevisiae alpha mating factor secretion signal for recombinant protein secretion in Pichia pastoris (opens in a new tab)

Rational design, characterization and in vivo studies of antibody mimics against HER2

Su, Dan2018

… interactions of HER2-Pertuzumab complex and Knob-Socket model can be developed to design antibody mimics for targeting HER2. All designed antibody mimics were simulated and docked with HER2 using Molecular Operating Environment (MOE) software to estimate binding energy and analyze the detail …

u-pacific Repository record for Rational design, characterization and in vivo studies of antibody mimics against HER2 (opens in a new tab)

Design and applications of antibody mimics against epidermal growth factor receptor

Sachdeva, Sameer2018

… CDR binds and modifying sequences using knob-socket computational model. The binding of antibody mimics were first analyzed by using MOE to obtain the binding energy, total and preserved interactions as compared to the interactions between EGFR and Cetuximab. Further, the designed …

u-pacific Repository record for Design and applications of antibody mimics against epidermal growth factor receptor (opens in a new tab)

Exploring the molecular architecture of proteins: Method developments in structure prediction and design

Chavan, Archana G.2018

<p>Proteins are molecular machines of life in the truest sense. Being the expressors of genotype, proteins have been a focus in structural biology. Since the first characterization and structure determination of protein molecule more than half a century ago1, our understanding of protein structure …

u-pacific Repository record for Exploring the molecular architecture of proteins: Method developments in structure prediction and design (opens in a new tab)