Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Klotho"”.
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THE ROLE OF BETA-KLOTHO PROTEIN IN NAFLD PATHOGENESIS
… that the rs17618244 G>A variant in the β-Klotho (KLB) gene dampened the KLB hepatic/plasma levels, leading to inflammation, ballooning, and fibrosis in NAFLD patients. KLB protein, functioning as coreceptor for fibroblast growth factor receptors 4 (FGFR4), mediates in the liver the …
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Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury
… is an urgent need for a solution. Soluble alpha-Klotho (herein termed Klotho) is a pleiotropic protein essential for tissue maintenance and protection. Transmembrane Klotho is synthesized mainly in the kidney and cleaved at the transmembrane site of renal tubules for circulation to extra-renal …
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Τα επίπεδα του αυξητικού παράγοντα των ινοβλαστών 23 (FGF23) και της πρωτεΐνης Klotho σε σχέση με την ηλικία και τη νεφρική επαναρρόφηση φωσφόρου στην παιδική ηλικία
… ρόλο στην ομοιόσταση φωσφόρου. Η πρωτεΐνη Klotho είναι ο συμπαράγοντας του FGF23 που μεσολαβεί τη σύνδεση του FGF23 στον υποδοχέα του. Στη βιβλιογραφία για τα υγιή παιδιά υπάρχουν λίγα δεδομένα για τον FGF23 και ακόμη λιγότερα για το Klotho. Σκοπός μελέτης: Nα διερευνήσουμε την ύπαρξη …
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The human Klotho VS variant: focus on the processing and function of the V, S and VS isoforms
Klotho (KL), an anti-aging protein, attracted interest in the aging field because of the dramatic phenotype of KL deficient mice and its connection to signaling pathways implicated in aging. The KLVS variant consists of the F352V (KLV) and C370S (KLS) substitutions. It was detected in genome wide …
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Affinity Maturation of Peptides to Bind Protein-Protein Interfaces
… the aging-related transmembrane protein α-Klotho, co-receptor in the fibroblast growth factor 23 receptor complex. Reduced α-Klotho levels indicate chronic kidney disease and other age-related diseases. The long-standing difficulty in detecting or labeling α-Klotho prevented us to …
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Alteraciones del metabolismo óseo y mineral de la enfermedad renal crónica en la diabetes
… por un lado, la correlación existente entre Klotho soluble (sKlotho; en sangre y orina) y niveles de Klotho en riñón y, por otro, la relación entre los niveles de sKlotho, vía de Wnt/β-catenina y niveles de productos finales de glicación avanzada (AGEs) y sus receptores (RAGE).
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… VDR target gene we identified in the islet is klotho, a key regulator of phosphate homeostasis. We clearly establish that klotho mRNA and protein are detected in beta cells of mouse islets, at levels sufficient to mediate signal transduction pathways via klotho’s role as a co-receptor for …
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ΕΠΙΔΡΑΣΗ ΤΗΣ ΜΗΧΑΝΙΚΗΣ ΦΟΡΤΙΣΗΣ ΣΕ ΦΥΣΙΟΛΟΓΙΚΟΥΣ ΚΑΙ ΓΗΡΑΣΜΕΝΟΥΣ ΣΚΕΛΕΤΙΚΟΥΣ ΜΥΟΒΛΑΣΤΕΣ
… ρυθμιστής μυϊκής ανάπτυξης και ο παράγοντας Klotho, που έχει συνδεθεί με αντιγηραντικές ιδιότητες. Τα κύτταρα καλλιεργήθηκαν σε Passage 14 (φυσιολογικός φαινότυπος) και Passage 36 (γηρασμένος φαινότυπος) και υποβλήθηκαν σε κυκλική μηχανική φόρτιση (15% επιμήκυνση, 1 Hz, 12 ώρες). Η σχετική …
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
… The pancreas also expresses the FGFR1/beta-klotho receptor complex that FGF21 binds to elicit downstream signaling. The physiological function of FGF21 in the exocrine pancreas is to stimulate digestive enzyme secretion by triggering intracellular calcium release through …
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Riesgo vascular en el paciente alcohólico.
… siendo el FGF-23 y su correceptor alpha klotho sus principales protagonistas. Sin embargo, nunca he sido estudiado el comportamiento de estas moléculas en pacientes alcohólicos. En este estudio analizamos el comportamiento de este eje en 82 pacientes ingresados en un servicio de Medicina …
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Molecular Genetic Analysis of FGF23 Bioactivity in the Bone-Kidney Endocrine Axis
… FGF23 requires a signaling complex composed of Klotho and an FGFR for bioactivity, however, the location and composition of the signaling complex is unknown. Klotho localizes to the renal distal convoluted tubule, whereas the sodium phosphate co-transporters are expressed within the renal …
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Metabolismo mineral en niños con deficiencia subclínica de vitamina D. Implicaciones del Factor de Crecimiento Fibroblástico 23 (FGF23).
… D (1,25(OH)2D). 25OHD, for ma soluble de a-klotho (sKL), fosfatasa alcalina, creatinina, albúmina, calcio y fosfato) y hormonales (FGF23 y PTH) en suero y orina. Se recopiló información mediante encuestas telefónicas sobre etnia, enfermedades crónicas, suplementos vitamínicos, exposición …
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Comparison of Biochemical mechanisms of cigarette smoke and heated tobacco aerosol toxicity on microglial cell function under physiological and pathological conditions [Confronto dei meccanismi biochimici della tossicità del fumo di sigaretta e dell'aerosol di tabacco riscaldato sulla funzione delle cellule microgliali in condizioni fisiologiche e patologiche]
… l'espressione del marcatore dell'invecchiamento Klotho β. Al contrario, l'aerosol di HTP presenta una minore tossicità microgliale, con una ridotta produzione di ROS, perossidazione lipidica e disfunzione mitocondriale rispetto alle sigarette convenzionali. Questi risultati evidenziano il …
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Generative Machine Learning Models for RNA Structure Prediction and Design
… models (DDPMs). Our folding model, named Klotho, captures local atomic interactions and structural features using SO(3)-equivariant message passing layers with a point cloud data representation. Ablation studies confirm that Klotho’s model performance scales with higher dimensionality and …
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Relación entre el factor de crecimiento fibroblástico 23 (fgf23) y el fenómeno inflamatorio en la enfermedad vascular aterosclerótica
… perfil de expresión del FGF3 y de su correceptor Klotho en células circulantes de sangre periférica (CCSP) y en la pared arterial mediante qPCR, y en esta última además mediante inmunohistoquímica, así como sus concentraciones séricas mediante inmunoensayo ELISA, estudiándose la relación de estos …
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Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… through cell-surface receptors complexed with β-Klotho, a membrane-spanning protein, to mediate signaling cascades that lead to physiological responses. One member, FGF19, causes reduced glucose and insulin levels with enhanced insulin sensitivity when expressed in transgenic mice. Another …
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Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models
… dietary BCP improved the serum concentrations of klotho (P < 0.05). In summary, these data indicate that BCP enhances the level of klotho in the serum, leading to improved bone properties and mineralization in an experimental mouse model. Under conditions lacking UV light, the D-deficient diet …
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Ceramide Accumulation in the Alpha Cell Drives Glucagon Secretion and Hyperglycemia
… impairment by deletion of its coreceptor beta-klotho are the three novel approaches outlined in this body of work to elucidate the effects of ceramides on glucagon secretion.