Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Kisspeptin"”.
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In-vivo analysis of hypothalamic kisspeptin neuron activity patterns
… controlled by two populations of hypothalamic kisspeptin neurons located in the arcuate nucleus (ARNKISS), known as the pulse generator, and in the rostral periventricular area of the third ventricle (RP3VKISS) operating as the surge generator. The pituitary gland responds to GnRH by releasing …
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The role of progesterone receptor in hypothalamic kisspeptin neurons
In recent years, the neuropeptide kisspeptin, secreted by kisspeptin neurons, has been identified as the prime regulator of gonadotropin releasing hormone (GnRH). Kisspeptin neurons express steroid hormone receptors through which gonadal steroids exert both positive and negative feedback to the …
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Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
… cells. There is evidence that the hormone, kisspeptin, plays a role in the development of immune tolerance during pregnancy based on its role in the regulation of the adaptive T regulatory (aTreg)/T-helper 17 (Th17) cells, induction of the enzyme indoleamine 2,3-dioxygenase (IDO) and …
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The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity
… antioxidant enzyme that specifically binds Aβ. Kisspeptin (KP) is a product of the KiSS-1 gene and contains an Aβ binding domain, which also interacts with Aβ. The localization of catalase, KP and Aβ in the AD brain plus the effects of catalase and KiSS-1 overexpression in neuronal cells were …
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Kisspeptin and neurokinin B in the regulation of the human hypothalamic-pituitary-gonadal axis
Background: Hypothalamic kisspeptin and neurokinin B (NKB) are central regulators of GnRH and thus gonadotropin (LH and FSH) secretion. Men and women with loss-of-function mutations in NKB-kisspeptin pathway show hypogonadotropic pubertal delay with reduced GnRH/LH pulsatility. Studies in patients …
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The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation
… experiments and animal studies. Recently kisspeptins and their cognate receptor GPR-54 originally involved in tumour metastasis suppression and regulation of puberty, have been implicated in the inhibition of trophoblast invasion. Expression levels of kisspeptin and its receptor in …
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The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration.
Kisspeptin receptor, also known as KISS1R, is the endogenous receptor for the ligand peptide, kisspeptin. It is a G-protein coupled receptor that couples through the Gαq/11 pathway. It has been shown that KISS1R activation by kisspeptin results in the activation of phospholipase C, calcium …
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Interactions of GPR54 and GPR147 receptors with RF-amide ligands
… the GPCR GPR54 and its cognate peptide ligand, kisspeptin (an RFamide peptide), in the regulation of reproduction. Kisspeptin and GPR54 play a critical role in the control of the hypothalamic-pituitary-gonadal axis by regulating gonadotropin-releasing hormone secretion. Despite the physiological …
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Progesterone Regulation of the GnRH Pulse Generator
Kisspeptin neurons in the arcuate nucleus (ARN) represent the gonadotrophin- releasing hormone (GnRH) pulse generator responsible for driving the pulsatile release of GnRH and luteinising hormone (LH) secretion. In a healthy menstruating woman, following the mid-cycle ovulation, progesterone (P4) …
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The Role of Neurokinin B in the Regulation of the Preovulatory LH Surge in Ewes
… those containing neurokinin B (NKB) and kisspeptin.;Kisspeptin has been identified as a potent stimulator of LH secretion in a variety of species. GnRH neurons express the kisspeptin receptor (Kiss1r), indicating that kisspeptin can directly stimulate GnRH secretion. Two anatomically …
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Evaluation of the Hypothalamic Kisspeptin System Throughout the Estrous Cycle and During the Attainment of Puberty in Gilts
<p>Kisspeptin has been demonstrated to affect reproductive cyclicity and the attainment of puberty in multiple species, presumably through its actions on GnRH and LH, as demonstrated in other species. Kisspeptin administration causes increased plasma concentrations of LH in pigs, sheep, and rats. …
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The reproductive biology of two small southern African mammals, the spiny mouse, Acomys spinosissimus (Rodentia: Muridae) and the Eastern rock elephant-shrew, Elephantulus myurus (Macroscelidea: Macroscelididae)
… A number of recent studies have suggested that kisspeptin may play a major part in the regulation of the hypothalamo-pituitary-gonadal axis and ultimately reproduction. The exact role of kisspeptin signalling in seasonal breeders is, however, unclear. The present study investigated the …
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Modeling “Abnormal” Ovulatory Dynamics: Enzymes, Insulin, and the Impact of Stress
… including gonadotropin-releasing hormone, kisspeptin signaling, and the ovulatory cycle. Integral to our model development, we define ovulatory criteria, conduct an extensive global sensitivity analysis, and fit parameters to clinical hormone data throughout the ovulatory cycle. We then …
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Role of obesity and gestational diabetes mellitus status on the expression of kisspeptin, inflammatory markers and other endocrine signals, and their correlation with foetal outcomes and placental structure
… glucose control. Current literature links kisspeptins with glucose-stimulated insulin secretion, and low plasma kisspeptin concentrations have been associated with GDM and markers of insulin resistance. In addition, maternal obesity is characterized by low-grade inflammation and insulin …
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Dysregulation in polycystic ovary syndrome: mechanisms and therapeutic approaches
… stem cell therapy, gene-targeted treatments, kisspeptin-based therapies, and interventions targeting the gut microbiome. While PCOS does not yet have a cure,scientific advancements are bringing the possibly of personalized, lasting treatments closer to reality. This thesis examines the role of …
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Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… the effect that Notch had on the development on kisspeptin expressing neurons of the ARC involved in control of reproductive function. We observed that both in an early genetic ablation of canonical Notch signaling (Rbpj cKO) as well as a persistent Notch signaling expressing (NICD tg) mouse …
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Characterization and Role of Secretogranin-II/Secretoneurin in Zebrafish Reproduction
… that gonadotropin-releasing hormone and/or kisspeptin are required for pulsatile and surge release of luteinizing hormone in mammalian species, their essentiality is challenged by studies showing knockouts in zebrafish and medaka do not block reproduction. In goldfish, secretoneurin-a, a …
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The gonadotropin-releasing hormone (GnRH) system: a comparison between breeding and non-breeding naked mole rats (Heterocephalus glaber)
… factor involved. Many other hormones (such as kisspeptin, gonadotropin-inhibiting hormone and neuropeptide Y) may influence GnRH and sexual maturity, and future studies would benefit from a multi-layered approach to investigate suppression of reproduction in naked mole rats.
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Intrinsic Neuronal Plasticity of Kiss1 Neurons in Mice around Puberty
Puberty is a critical stage in mammalian development, characterized by rapid somatic growth, sexual maturation, and the final maturation of the central nervous system. The timing of puberty is crucial, as initiating it either too early or too late can lead to adverse outcomes. Precocious puberty …
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Transcriptomic Profiling of Hypothalamic Kiss1 Neurons
Kisspeptins, peptide products of the Kiss1 gene, are critical players in the reproductive function, particularly as major upstream neuroendocrine regulators of the Hypothalamic-Pituitary-Gonadal (HPG) axis. Kisspeptins are crucial for gonadotropin releasing hormone (GnRH) secretion, and …
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