Global ETD Search
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Showing 1 to 7 of 7 for “"Kir4.1"”.
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Aquaporin 4 and Kir4.1 Distribution in Retinal Glial Cells of Normal Macaque Eyes and Eyes with Experimental Glaucoma
… and a potassium inward rectifying channel (Kir4.1) in the Müller glia and astrocytes of the normal macaque monkey retina and to see how the distribution changed in eyes with experimental glaucoma. Methods: Five Rhesus macaque monkeys, ranging in age from 7 to 11 years, had experimental …
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Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
… transgener Maustechnologie gezeigt werden, dass Kir4.1 früh postnatal zunächst Zellkörper-assoziiert auf Oligodendrozyten in der weißen Substanz des Rückenmarks exprimiert wird. Im weiteren Verlauf der Entwicklung kommt es zu einer Hochregulation der Proteinexpression auf perivaskulären und …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
… factor receptor TrkA, the potassium channel Kir4.1, glial fibrillary acidic protein (GFAP), SGC p75NTR, connexin 43, we intrathecally infused p75NTR anti-sense oligonucleotides (AS OGN), previously shown by Obata et al. (2006) to effectively suppress p75NTR expression in intact neurons. Male, …
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The role of potassium buffering and apoptosis of trigeminal satellite glial cells in the induction and maintenance of orofacial neuropathic pain in rats
… and protein levels and gene expression of the Kir4.1 and the SK3 potassium channels and gap junction protein connexin 43 (Cx43). We evaluated apoptosis endpoints including protein levels and gene expression of apoptotic related proteins bcl-2, caspase 9, caspase 3 and p53. Results indicate that …
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Charakterisierung von Calcium-Transienten in Astrozyten der ventralen respiratorischen Gruppe
… dass der einwärts gleichrichtende Kaliumkanal Kir4.1 das essenzielle molekulare Substrat für ein astrozytenspezifisches Calciumsignal darstellt, welches durch Absenken des extrazellulären Kaliums induziert wird. Mit Hilfe transgener Mäuse mit fluoreszenzmarkierten Zellpopulationen konnte das …
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Astrocytic Sonic Hedgehog signalling in development and disease
… are enriched for the Shh-responsive gene KCNJ10 (Kir4.1), with overlapping proteomic expression of Shh and Kir4.1 observed near the ventricular regions. Using EdU and Ki67 staining, I elucidated a role for Kir4.1 in regulating astroglial progenitor cell proliferation and cell cycle dynamics. These …
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The Role of Microglia and Astrocyte in Spinocerebellar Ataxia Type 1
… on astrocytes and in particular, astrocytic Kir4.1/Kcnj10. Astrocytic Kcnj10 was downregulated throughout the brain of the knock-in Atxn1154Q/2Q mouse line. To investigate the potential role of cell-autonomous effects of Atxn1 on astrocytic transcription, I used the novel conditional …