Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Kinome Profiling"”.
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Global characterization of oncogenic kinase signaling
… integrating mass spectrometry-based quantitative kinome profiling and siRNA-based functional genomics screens was applied to provide insights into this problem. Firstly, a novel broad-spectrum kinase inhibitor CTx-0294885 was developed and characterized as a kinase-capturing tool in order to …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… which relied on Notch signature in tumor cells. Kinome profiling revealed that OncoD-0J1 treatment suppressed CDK1, resulting in a G2/M cell cycle checkpoint as seen by cell cycle analysis. Cell cycle arrest led to senescence and correlated with increased reactive oxygen species, p62 …
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Multi-omic Studies of Neutrophils Reveal Programmed Deactivation Phenotypes After Inflammatory Stimulus
… investigation include proteome, phosphoproteome, kinome, and transcriptome profiling. Data interpretation was facilitated through clustering and pathway enrichment analysis. This multi-omic approach was complemented by a multi-parametric assay of neutrophil functions. Analysis of the …