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Showing 1 to 16 of 16 for “"Kininogen"”.
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Kininogen and Ferritin in Tumorigenesis
High molecular weight kininogen (HK) is a plasma glycoprotein which serves as a cofactor in the intrinsic coagulation cascade, and it is also known as an inhibitor of cysteine proteases. HKa can interact with a variety of cells including endothelial cells, neutrophils, monocytes and platelets. When …
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Elucidating the Ferritin-High Molecular Weight Kininogen Domain 5 Interaction
… modulator is derived from high molecular weight kininogen, or HK, a plasma protein involved in the intrinsic blood coagulation pathway. Once HK is cleaved by kallikrein or another protease, HKa is produced, which is capable of reversibly binding to endothelial cells in the presence of …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
The kininogen-deficient BNK rats were shown to progressively develop salt-sensitive hypertension by accumulation of Na+. It was believed that the kininogen-deficiency is responsible for the defective NaCl excretion leading to a cardiovascular damage. In addition to the kallikrein-kinin system …
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¿PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE ATTACK¿
… from the cleavage of the high molecular weight kininogen and is catabolized mainly by ACE. During acute attacks of C1-inhibitor deficiency angioedema, high levels of cleaved high molecular weight kininogen (marker of bradykinin generation) were observed, thus indicating that the high …
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Host response in sepsis
… by decreased levels of high-molecular-weight kininogen. The levels of the main effector, bradykinin, were, however, also decreased, suggesting substrate depletion in the state of established severe sepsis.
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Analyse von Proteinen und deren Elimination durch drei verschiedene extrakorporale Therapieverfahren der LDL-Apherese bei Patienten mit familiärer Hypercholesterinämie mittels Proteomics-Methoden
… in die intrinsische Gerinnungskaskade (z.B. Kininogen 1), Proteinen mit Adhäsionsfunktion (z.B. Fibronektin), immunologisch, entzündlich (z.B. Haptoglobin und Komplement-Komponenten) und rheologisch relevante Proteine (z.B. Fibrinogen). Eine Quantifizierung dieser Ergebnisse mittels …
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ANTIMICROBIAL ACTIVITIES OF HISTIDINE-RICH GLYCOPROTEIN AND CATIONIC PEPTIDES
… histidine-rich peptides derived from domain 5 of kininogen and histidine-rich glycoprotein (HRGP). HRGP, an abundant heparin-binding plasma protein, exerted antimicrobial effects against Gram-positive and Gram-negative bacteria and fungi. The antibacterial activity of HRGP was dependent on …
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Kinin System Activation in Vasculitis
… system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. Vasculitis is an autoimmune …
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Novel Endogenous Antimicrobial Peptides
… cell-binding domain 5 of high molecular weight kininogen, a substrate in the intrinsic pathway of coagulation. Interestingly, the peptide HKH20 (His479 His498) from this domain was active in high salt, and highly resistant to degradation by various bacterial proteases. The understanding that …
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Molekulare Analyse der mRNA-Expression von Plasma-Prokallikrein
… humanen Geweben. Die mRNAs von hochmolekularem Kininogen (HK), niedermolekularem Kininogen (LK), Faktor XI (FXI) und Faktor XII (FXII) werden dagegen nur in wenigen Geweben exprimiert. Die Transkripte von HK, LK und FXI findet man außerhalb der Leber nur noch in Nierengewebe in signifikanter …
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Screening Of Natural Products For Their Effect On Kallikrein-Kinin System: Potential Implications In The Treatment Of Hereditary Angioedema
… (BK) release from high molecular weight kininogen (HMWK). The primary objective of this study was to screen natural products with anti-inflammatory properties for their effects on the components namely HMWK, PK, FXIIa and FXIa. Terminalia chebula fruit, Terminalia bellirica fruit, …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… Kallikrein cleaves high molecular weight kininogen (HK) to liberate the potent pro-inflammatory peptide bradykinin (BK). BK upon activation of its constitutive B2 receptors on endothelial cells leads to an increase in intracellular Ca2+ level and subsequent production of nitric oxide (NO) …
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Immunological and biochemical techniques in the analysis of tear proteins
… of a lesser understood and investigated protein, kininogen, was also estimated, in particular, in relation to contact lens wear. Difficulties arise when attempting to extract proteins from the contact lens in order to examine the individual nature of the proteins involved. These problems were …
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The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia
… B-CLL cells. One of the protein targets found (kininogen) was increased by over two-fold in three independent clinical samples after sustained BCR stimulation. If we understand more about the BCR signaling pathways then we may be able to identify potential prognostic biomarkers and novel targets …
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Characterization of Prolylcarboxypeptidase Expression Pattern in Rat Cardiomyocytes in Nutrition Overload Conditions
… (BK) liberation from high molecular weight kininogen (HK). PK is activated to kallikrein by PRCP, implicating a role for PRCP in the coagulation pathway. The resultant kallikrein will activate FXII which in a reciprocal manner leads to the activation of FXI. Lastly, by metabolizing α-MSH1-13 …
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Polyphosphate and tissue factor/factor VIIA as initiators of coagulation
… an important cofactor, high molecular weight kininogen, also binds to anionic surfaces and has been demonstrated as important for mediating the activities of contact pathway proteins. Nonetheless, it is often overlooked when studying the contact pathway in vitro. To investigate the …