Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Kinin"”.
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Kinin System Activation in Vasculitis
The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. Vasculitis is an …
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Inflammation, kinins, and kinin receptors
… to an exacerbation in many disease areas. Bradykinin (BK) belongs to the group of vasoactive peptides, so-called kinins, which are potent inflammatory mediators. BK, once released from the human contact system, elicits a transient inflammatory response via activation of the constitutively …
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Nachweis der Kinin-B1-Rezeptor-Hochregulation im Schwein bei Tieren mit einer vorbestehenden Infektion
… und chronischen Entzündungsreaktion gelten Bradykinin und seine Derivate. Als Rezeptoren dieser Kinine sind der Kinin B2- und B1-Rezeptor bekannt. Ziel dieser Arbeit war der Beweis einer Kinin B1-Rezeptorhochregulation im Rahmen der inflammatorischen Antwort bei Schweinen, die unter natürlichen …
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Screening Of Natural Products For Their Effect On Kallikrein-Kinin System: Potential Implications In The Treatment Of Hereditary Angioedema
… of activated factor XII (FXIIa) and bradykinin (BK) release from high molecular weight kininogen (HMWK). The primary objective of this study was to screen natural products with anti-inflammatory properties for their effects on the components namely HMWK, PK, FXIIa and FXIa. Terminalia …
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Role of kinins in mediating vascular function in healthy pregnancy and pre-eclampsia
… to the development of the maternal syndrome. Kinins are endogenous peptides released by the endothelium that contribute to the regulation of cardiovascular homeostasis by inducing vasodilation, fibrinolysis and angiogenesis. Given that pre-eclampsia is associated with reduced …
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Streptococcal virulence and the coagulation system.
… pathway of coagulation and the kallikrein-kinin system in human plasma, as well as to how these surface proteins are produced in different growth phases. The interactions involve activation of the kallikrein-kinin system and inhibition of its antibacterial effects. Inspired by these …
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¿PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE ATTACK¿
… cases remain idiopathic. The role of bradykinin in increasing vascular permeability has been demonstrated in angioedema due to C1-inhibitor deficiency and in angioedema due to the treatment with angiotensin converting enzyme (ACE) inhibitors, while its involvement in idiopathic angioedema …
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Studies on the angiotensin converting enzyme gene polymorphism and Ace inhibitors
… tissue ACE is unknown. ACE inhibition increases kinin level, for example bradykinin. Kinins have been proposed be involved in the pathogenesis of cough due to ACE inhibitors, a common adverse effect in those prescribed these drugs. A genetic link was proposed to explain the differing …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
The kininogen-deficient BNK rats were shown to progressively develop salt-sensitive hypertension by accumulation of Na+. It was believed that the kininogen-deficiency is responsible for the defective NaCl excretion leading to a cardiovascular damage. In addition to the kallikrein-kinin system …
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Bioactive peptides from the defensive skin secretions of selected American and Asian frogs
… work on these bioactive substances such as bradykinin-related peptides and antimicrobial peptides, indicates that they have some clear clinical therapeutic implications including uses as anti-inflammatories, anti-bacterials and even anticancer agents. This project mainly focused on the isolation …
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
… clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced extracellularly following pathological insults and tissue damage. These peptides act through two GPCR subtypes, B1 (B1R) and B2 (B2R), to elicit numerous inflammatory responses including …
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The extreme anterior domain coordinates brain and craniofacial development
… that precede mouth opening. During this process, Kinin-Kallikrein signaling from the EAD is required to guide neural crest cells into the face. After their migration, neural crest cells signal back to the EAD to regulate pre-mouth array morphogenesis via Wnt/PCP signaling. Formation of the …
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Human testis angiotensin-converting enzyme: crystal structure of a glycosylation mutant and investigation of a putative hinge-mechanism by normal mode analysis
… via the renin-angiotensin and kallikrein-kinin systems. A number of orally active drugs have been developed over the years that target somatic ACE, for the treatment of hypertension, myocardial infarction and congestive heart failure. Protein structural information about ACE is an …
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The influence of carrageenans on the cells and pathways of haemostasis and their role in immunosuppression
… activity.<br/><br/>3. The kallikrein-kinin pathway, like fibrinolysis, may be triggered through Factor XII activation. In vitro results suggest that carrageenan inhibits prekallikrein activation while ex vivo an initial potentiation was observed.<br/><br/>4. In the formation of a …
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The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia
… lymphoma kinase (ALK), the plasma kallikrein-kinin system (KKS), the AKT-1 pathway, the MAPK pathways, the adenylate kinase system and involvement in the CD40-dependant activation of B-CLL cells. One of the protein targets found (kininogen) was increased by over two-fold in three independent …
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Molekulare Analyse der mRNA-Expression von Plasma-Prokallikrein
… sowohl in der Fibrinolyse als auch im Kallikrein-Kinin-System eine zentrale Rolle. Neuere Arbeiten haben gezeigt, dass PPKmRNA auch außerhalb der Leber exprimiert wird. Daraus ist zu schließen, dass dort ebenfalls PPK-Protein gebildet wird und dass diesem extrahepatischen, gewebeständigen PPK bzw. …