Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Kinetoplastid"”.
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Assessment of flagellate diversity at deep-sea hydrothermal vents using the combined approach of culture-dependent and culture-independent methods
… Choanoflagellida, Chrysomonadida, and Kinetoplastida. Molecular and ultrastructural evidence point to one of the isolates, Ancyromonas, as a plausible candidate for the closest relative to the common ancestor of Metazoans, Fungi, and Choanoflagellates (the Opisthokonta). Using l8S rDNA …
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Evolution of vesicular transport in kinetoplastids: dynamics and novel gene products
… those belonging to the highly divergent order Kinetoplastida. Kinetoplastid parasites are etiological agents of several neglected tropical diseases such as African sleeping sickness, Chagas disease, and Leishmaniasis. Newly available sequences of many kinetoplastid genomes were used to …
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Unravelling the molecular mechanisms of Leishmania mexicana adhesion in the sand fly vector
… for cell morphogenesis. While three essential kinetoplastid-insect adhesion proteins (KIAPs) are known, the overall proteome of the adhesion complex is obscure. Moreover, the contribution of the FAZ in adhesion and its relationship with the KIAPs remains unclear. Furthermore, in the motile …
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Identification and functional characterization of the mitochondrial adenine nucleotide carriers of Trypanosoma brucei
… of all eukaryotes. In the genome of the kinetoplastid parasite Trypanosoma brucei, three putative ADP/ATP carrier sequences (MCP5, MCP15 and MCP16) and one GDP/GTP (MCP13) entries were analyzed by sequence analyses and phylogenetic reconstruction. AACs phylogenetic reconstruction proved a …
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The PUF proteins in Trypanosoma brucei
… analysis suggested that there were several kinetoplastid PUF proteins before separation from the eukaryotic lineage. Depletion of each of the nine T. brucei PUF proteins by RNA interference did not result in an obvious phenotypic change. Furthermore, PUF1 knock out procyclic cell lines were …
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Target Identification and Mechanism of Action Studies in Folate Metabolism in Kinetoplastids
… drug targets. The same cannot be said for the kinetoplastids. Drug discovery programmes have focused on targeting enzymes of the folate metabolism with very little clinical success. Despite showing significant inhibition of the parasitic enzymes, potency is seen to decrease in cellular and …
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Cloning and characterization of a single-stranded DNA-binding protein of Leishmania major
… the process of polycistronic gene expression in kinetoplastid protozoans.
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The eco-epidemiology of Chagas disease risk in Panama
… (Hemiptera: Reduviidae). Trypanosoma cruzi, a kinetoplastid protozoan parasite and causative agent of Chagas disease, is shed in the feces of triatomines during blood-feeding and must enter the bloodstream through the bite wound or mucous membranes. Intensive studies into the domestic …
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Biochemical characterisation of a novel vaccine candidate against Trypanosoma vivax, the cell surface glycoprotein IFX
… Antigen from Trypanosoma vivax (IFX) from the kinetoplastid parasite Trypanosoma vivax. African trypanosomes are unicellular protozoan parasites and pathogens from the family Trypanosomidae, able to infect nearly all mammalian species. African animal trypanosomiasis (AAT) affects both …
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New therapeutic strategies against trypanosomiasis and leishmaniasis
… Trypanosomiasis are diseases caused by the Kinetoplastida parasites of Leishmania sp. and Trypanosoma sp. respectively. Control and management of these diseases, which affect a significant number of people in the tropics and subtropical areas of the world, is beset with numerous problems …
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Investigation of Trans-factors responsible for the developmentally linked instability of a highly regulated mRNA in Trypanosoma brucei
*Trypanosoma brucei*, a protozoan pathogen of both humans and livestock, has a number of divergent features arising from its history as an early branching eukaryote. One such feature is an RNA polymerase II gene expression system in which genes of diverse functions and expression profiles are …