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Showing 1 to 11 of 11 for “"Kinases protein"”.
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The discovery and anticancer preclinical investigation of novel piperazinylpyrimidine derivatives designed to target the human kinome
… derivatives designed to target kinases protein family. Primary screening of the antiproliferative effects implemented by these successfully synthesized new agents has resulted in the candidacy of 4 , 15 , and 16 as not only prototype representatives of the class, but surprisingly …
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Identificação de componentes da via de sinalização mediada pela proteína NIK, um receptor que interage com a proteína NSP de geminivírus
… a um estímulo desconhecido, NSP-interacting kinases (NIKs) são ativadas após a formação de dímeros e autofosforilação intermolecular. A inibição da autofosforilação de NIK por NSP e a inativação de genes NIKs aumenta a suscetibilidade à infecção viral, sugerindo que esta proteína estaria …
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ΦΩΣΦΟΡΥΛΙΩΣΗ ΠΡΩΤΕΙΝΩΝ ΣΕ ΣΥΣΤΗΜΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΕΛΕΥΘΕΡΟ ΚΥΤΤΑΡΩΝ ΑΠΟ ΣΥΚΩΤΙΠΟΝΤΙΚΟΥ. ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΜΙΑΣ ΝΕΑΣ ΚΙΝΑΣΗΣ ΠΡΩΤΕΙΝΩΝ ΠΟΥ ΡΥΘΜΙΖΕΤΑΙ ΑΠΟ ΚΥΚΛΙΚΑ ΝΟΥΚΛΕΟΤΙΔΙΑ
… AN INVESTIGATION ON THE PHOSPHORYLATION OF THE PROTEIN COMPONENTS OF A CELL FREE SYSTEM OF PROTEIN SYNTHESIS OF MOUSE LIVER (POLYSOMES,"PH5" FRACTION) AS WELL AS THE EFFECT OF VARIOUS AGENTS ON PROTEIN PHOSPHORYLATION IS REPORTED. THE ENZYME IS A SERINE- THREONINE KINASE WITH A MOLECULAR MASS OF …
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
… pathway have been discovered including RIP1/3 kinases and MLKL, which together, form the core of the necrosome complex. RIP3-dependent phosphorylation of MLKL promotes the formation of high molecular weight MLKL polymers that disrupt the integrity of the plasma membrane leading to cell death. …
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Interaction Mapping of the Atypical Protein Kinase WNK3
The story of the protein kinase "with no lysine 3" (WNK3) represents a unique chapter in the larger story of protein kinases, the so-called 'molecular switches' of the cell that serve the vital function of phosphorylating myriad proteins. In doing so, these enzymes furnish the cell with one of the …
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Safeguard of Mitosis: The Spindle Checkpoint
… sensing and checkpoint signaling. Of kinetochore proteins, the KMN network acts as both a critical microtubule receptor and a signaling platform for the spindle checkpoint. The human KMN contains the kinetochore null 1 complex (Knl1C), the minichromosome instability 12 complex (Mis12C), and the …
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Protein kinases: Structure modeling, inhibition, and protein-protein interactions
<p>Human protein kinases belong to a large and diverse enzyme family that contains more than 500 members. Deregulation of protein kinases is associated with many disorders, and this is why protein kinases are attractive targets for drug discovery. Due to the high conservation of the ATP binding …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
Protein-protein interactions are essential for nearly every cellular process. Within signaling pathways, such interactions carry out numerous functions such as defining substrate specificity, inhibition of both other interactions and enzyme activity, localizing signaling partners, acting in a …
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Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… cell lung cancers (NSCLC). The SUMO E3 ligase protein inhibitor of activated STAT-1 (PIAS1) is one the few known SUMO conjugating enzymes known to date. PIAS1 was first discovered as a negative regulator of signal transducer and activator of transcription 1 (STAT-1), from which its name is …
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Novel peptide-based approaches to study the activity and substrate specificity of protein kinases
Protein phosphorylation, catalyzed by protein kinases, is the predominant post-translational modification made to proteins. This process is readily reversible, with protein phosphatases catalyzing removal of the installed phosphate groups. Together, protein kinases and phosphatases modulate the …