Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Kinase independent function"”.
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… relapse. Here, we identify focal adhesion kinase (Fak) as a critical regulator of metastatic reactivation and progression and describe a novel mechanism by which it facilitates immune evasion. Fak ablates stimulator of interferon genes (Sting)-dependent type I interferon production when …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… We have identified Pyk2, a FAK (focal adhesion kinase) family non-receptor tyrosine kinase, as a beta2-integrin-dependent regulator of rear contraction in migrating neutrophil cells. We show that Pyk2 is specifically activated by beta2-integrin and that Pyk2 mediates contraction by interaction …
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Novel Mechanisms of Kinase Independent Pro-Survival Functions of EGFR in Cancer
Tyrosine kinase activity of epithelial growth factor receptor (EGFR) plays an important role in regulating numerous signaling pathways in cancer. It is commonly overexpressed in various cancers. Several strategies for cancer therapy were developed to target the kinase function of EGFR. However, the …