Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Killer-cell Immunoglobulin-like Receptors"”.
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
Human circulating γδ T cells are broadly classified into three subsets: Vδ1, Vδ2, and Vδ1/2neg populations, with the Vδ2 subset being the most abundant. In this research, I focus on the contribution and interplay of Natural Killer (NK) receptors to the γδ T cell phenotype and function, with …
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Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta)
… Charakterisierung der genetischen Diversität der killer cell immunoglobulin like Rezeptoren (KIR) und die Interaktion zwischen KIR und MHC-Klasse-I Molekülen im Rhesusaffen (Macaca mulatta). In Menschen wurde gezeigt, dass KIR Haplotypen Auswirkungen auf die Resistenz gegen unterschiedliche …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
<p>Natural killer (NK) cell education is an essential developmental process for NK cell effector function, that renders some NK cells “licensed” and others “unlicensed” (with heightened or lowered effector function potential, respectively) against tumor and targets lacking self-molecules. However, …
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Immunotherapy and immunosuppression in myeloid leukemia
… by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
… 44 metastatic melanoma patients using known T-cell differentiation markers. We also compared CD8<sup>+</sup> TIL against the T cells from matched melanoma patients’ peripheral blood. We discovered a novel subset of CD8<sup>+</sup> TIL co-expressing early-differentiation markers, CD27, CD28, and …
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Characterisation of TAPBPR in immune cells
… threats, such as virus-infected or malignant cells. This is aided by cell surface glycoproteins called the major histocompatibility complex (MHC). MHC class I (MHC-I) molecules are polymorphic structures that can display a large repertoire of peptides. Peptide loading occurs in the context of …
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Untersuchungen zur immunologische Rolle von HFE, einem HLA Klasse I homologen Gen, das bei der hereditären Hämochromatose Punktmutationen zeigt
… Weise über eine <br>Interaktion mit KIRs (Killer cell immunoglobulin-like receptors) oder Lektin-ähnlichen <br>Rezeptoren das Lyseverhalten der NK- und gamma/delta T-Zell-Klone beeinflussen. Mit den <br>durchgeführten Bindungsassays mit KIR-Fc-Fusionsproteinen ließ sich keine Bindung von …
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Senescence and the Innate Immune System
Cellular senescence prevents deoxyribonucleic acid (DNA) damaged cells undergoing proliferation, protecting against malignancy but at the expense of senescent cell accumulation. Since the proportion of senescent hepatocytes in man correlates closely with liver injury, fibrosis stage and mortality, …