Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Killer cells"”.
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The elaborate interplay of natural killer cells and vaccinia virus
… known about the relationship between natural killer (NK) cells and VACV. Previous studies showed that during VACV infection, NK cells proliferate, are activated, limit viral replication, kill VACV-infected cells and display memory-like qualities. However, how NK cells recognise and interact …
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ROLE OF NATURAL KILLER CELLS IN THE PATHOGENESIS OF PRIMARY BILIARY CHOLANGITIS
… of small intrahepatic biliary epithelial cells (BECs), potentially leading to biliary cirrhosis and liver transplantation, if left untreated. As of now, anticholestatic therapy, in particular Ursodeoxycholic acid (UDCA), stands as the primary treatment approach for PBC, serving as the …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… defining the specificity and function of natural killer: NK) cells, their differentiation has not been fully elucidated. Previous studies of thymocyte development <italic> in vitro</italic> indicate that double negative: CD4<super>&minus</super>CD8<super>&minus</super>, DN) thymocytes can develop …
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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer
<p>NK cells are known to play an important role in the natural defense against viral infections and tumor immune surveillance. Through complex interactions between NK cell receptors and target cell ligands, transformed or unhealthy cells are identified and rapidly eliminated. NK cells have been …
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The role of natural killer cells in control of varicella zoster virus infection
… other components of the innate response, Natural Killer (NK) cells respond directly to VZV infection, and VZV is likely to use evasion strategies to modulate the immune response. This thesis explores the details of this interplay between NK cells and VZV. First, I address the hypothesis that NK …
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Crosstalk between natural killer cells and cancer associated fibroblasts in the tumour microenvironment
Cancer is a deadly disease where malignant cells proliferate and avoid elimination by the immune system. Although natural killer (NK) cells, of the innate immune response, recognise and eliminate cancer cells, their cytotoxic function is often impaired in the tumour microenvironment. Indeed, …
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The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection.
<p>Natural killer (NK) cells are non-specific killer cells of the innate immune system that eliminate target cells based on discrimination between self and non-self. Activation is carefully regulated through integration of signals received through both activating and inhibitory receptors. During …
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Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma
… and, to date, is incurable. Allogeneic natural killer (NK) cells are active in various hematologic malignancies and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and <em>ex vivo</em> expanded umbilical cord blood-derived NK (CB-NK) cells …
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The effects of calorie restriction and aging on natural killer cells in c57bl/6 mice
… response. This research focuses on natural killer (NK) cells in aged (22 mo) calorie restricted (CR) C57Bl/6 mice. NK cells are innate immune cells capable of killing tumor or virus-infected cells. We used flow cytometry to analyze NK cell maturation in young ad libitum (AL) fed, young CR, …
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Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells
… tested the hypothesis that activation of natural killer (NK) or lymphokine activated killer (LAK) cells induces the expression of FasL, perforin, and CD44 which together contribute towards increased cytolytic activity. To this effect, we used wild-type mice, perforin-knockout mice, and mice …
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MICROGRAVITY NEGATIVELY AFFECTS DNA DAMAGE REPAIR AND THE ANTI-LEUKEMIC FUNCTION OF HUMAN NATURAL KILLER CELLS
… shown that exposure of human hematopoietic stem cells (HSC) to mission-relevant doses of accelerated high-energy protons (the primary component of SEPs) and high atomic number and energy (HZE) ions (the high-energy nuclei component of GCR) induces DNA damage, alters HSC function/differentiative …
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Circulating Natural Killer Cells and Natural Killer Receptor Positive T Cells In Patients with Hepatitis C
… virus and develop chronic liver disease. Natural killer (NK) cells are thought to mediate immunity against viruses. They can lyse virus infected cells and release anti-viral cytokines. The roles of NK cells and natural killer receptor positive (NKR+) T cells in immunity agamst HCV is largely …
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Functional, phenotypic and morphological studies on the mechanism of tumor cytolysis by human natural killer cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterization of a Novel Receptor CS1 in Human Lymphocytes; Studies in Natural Killer Cells and B-Lymphocytes
… characterization of CS1 receptor in the natural killer (NK) cells and B lymphocytes was investigated. CS1 (CRACC, novel Ly9) is a novel member of the CD2 family receptor expressed on natural killer (NK), T cells, activated Bcells and dendritic cells. To examine the existence of isoform of CS1, …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… clearance of pathogens and tumors, in healthy cells, especially the terminally differentiated neurons in the nervous system, it is more desirable to protect cells from dying due to stress under pathological conditions. Thus, understating the inhibitory and the activating signals for RCD in …
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Characterization of cord blood natural killer cells: implications for cord blood transplantation and insights into natural killer cell differentiation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigating functions of tumor-infiltrating natural killer cells in genetically-engineered mouse models of non-small cell lung cancer
… that are poorly infiltrated by adaptive immune cells. I have explored the role of an innate immune effector known for its capacity to kill tumor cells and its importance in stimulating and shaping adaptive immune responses, the natural killer (NK) cell. To this end, I developed a new system for …
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UNVEILING HUMAN NATURAL KILLER CELLS ONTOGENESIS IN HOMEOSTATIC CONDITIONS AND DURING THE IMMUNE RECONSTITUTION AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION
Natural Killer (NK) cells are potent members of the innate immune system, as they are endowed with the capacity of sensing and eliminating tumor-transformed and viral infected cells by integrating a plethora of inhibitory and activating signals coming from a repertoire of germline encoded receptors …
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Cellular Immunity in Hamsters After Immunization With Vaccinia Virus: Studies on Macrophage Functional Heterogeneity and Interactions Between Natural Killer Cells and Macrophages
… and vaccinia virus-immune peritoneal exudate cells after separation on bovine serum albumin (BSA) discontinuous density gradients. The M(phi) subpopulations from normal and early- or late-immune animals were all phagocytic but differed in their ability to mediate cytotoxicity. Normal M(phi) …
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