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Showing 1 to 20 of 287 for “"Kidneys"”.
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Enzymatic blood group conversion of human kidneys for transplantation
… as a strategy to create “universal” blood group kidneys for transplantation. The principle of this strategy involves the cleavage of blood group antigens on the vascular surface of human kidneys by glycoside hydrolase enzymes, resulting in the conversion of blood group A or B substrates to a core …
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Conditions affecting the normal secretion of urea by the kidneys
Made available in DSpace on 2017-11-30T22:46:13Z (GMT). No. of bitstreams: 2 5957330.pdf: 5482605 bytes, checksum: de9a80ea1e36f8c26cbe8379338dde0d (MD5) license.txt: 4813 bytes, checksum: 715c4321821a960fa1a1e91d2ac7ebce (MD5) Previous issue date: 1895
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Optimizing the delivery of pre-transplantation therapies during normothermic machine perfusion of human kidneys
Despite a severe organ shortage, thousands of kidneys from higher-risk donors go unused each year. These marginal kidneys have an increased susceptibility to ischemia reperfusion injury and the use of these organs may ultimately result in post-transplant complications like graft loss and recipient …
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Cadmium and lead concentrations in livers and kidneys of cattle slaughtered at Grootfontein abattoir in Namibia
… of cadmium (Cd) and lead (Pb) in livers and kidneys of cattle slaughtered at Grootfontein abattoir in Namibia. The study design was based on the epidemiological principles to detect a single animal whose kidneys or liver contained Cd or Pb residues. The Grootfontein area of Namibia has …
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Interrelationships Between the Kidneys and Eccrine Sweat Glands of Man Intheir Electrolyte and Total Osmotic Excretions
Made available in DSpace on 2014-12-05T22:14:34Z (GMT). No. of bitstreams: 1 0010505.pdf: 3339574 bytes, checksum: 8faa42a8f04a0f1c265b1eb69100bc5e (MD5) Previous issue date: 1954
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Polycystic Disease of the Kidneys with special reference to its Clinical features, Radiological diagnosis and Genetic Nature
This work on polycystic disease of the kidney commenced while the author was engaged in general practice in Swellendam, in the South Western Cape from 1953-1956. Within a period of a year three patients, suffering from this disease, were seen. They were questioned about their family-relationship …
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Changes of Glomerular Filtration Rate of Donated and Remnant Kidneys in A Week after Living Donor Kidney Transplantation
… transplantation, the initial function of donor's kidneys will be split into the function of the donor's remnant kidney and the recipient's implanted kidney. The question whether the function of these remnant and implanted kidneys will change after donation and transplantation was addressed. …
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Bilateral cortical necrosis of the kidneys, a review of the literature with a report of four cases occurring during pregnancy
… of cases of bilateral cortical necrosis of the kidneys has chiefly fallen to the lot of the obstetrician. There are now, however, an appreciable number of recorded cases which have occurred without the common . association of pregnancy and indeed several cases have occurred in men.
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
… thesis, we extended the application of ASL into kidneys, aiming to establish ASL measured renal perfusion as a robust, accurate, and quantitative imaging biomarker with following sub-aims: (1) Improving the robustness of pseudo-continuous ASL for Renal Perfusion Imaging, (2) Proposing novel …
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Ischemic Preconditioning and Hydrodynamic Delivery for the Prevention of Acute Kidney Injury
… a prior injury. Ischemic preconditioning in the kidneys has been shown to confer protection onto kidneys from subsequent ischemic insults with attenuated serum creatinine values in treated rats. In the preconditioned kidneys, the enzyme IDH2 was discovered to be upregulated in the mitochondria. …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
… Over a range of 500 nM to 250 µM using a 150 pig kidneys and 80 declined deceased human kidneys, MitoQ was successfully taken up by pig and human kidneys in a concentration-dependent manner, resulting in stable tissue concentrations over 24 hours of cold storage followed by 6 hours of EVNP. The …
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Quantifying Renal Swelling during Machine Perfusion using Digital Image Correlation
While machine perfusion of explanted kidneys is theoretically superior to standard cold storage, it may damage potential transplants unless machine-associated swelling is controlled. This thesis presents the effects of perfusate tonicity on renal swelling during hypothermic machine perfusion. …
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Regulatory mechanisms in transplantation tolerance: the induction of tolerance by adoptive transfer in MHC-inbred miniature swine
… or unprimed peripheral regulatory cells and/or kidneys from long-term tolerant donor-matched swine. SLAdd miniature swine received 150 rads of whole body irradiation and class I-mismatched SLAgg kidneys from naive pigs with or without co-transplanted kidneys and/or cells from long-term tolerant …
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Studies of normothermic machine perfusion in human kidney transplantation
Normothermic machine perfusion (NMP) of human kidneys is a new preservation technique that allows for the assessment and treatment of kidneys prior to transplantation. However, there is currently no standard protocol for NMP of kidneys and limited understanding of the underlying mechanisms that …
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Targeting Glutamine Metabolism in Kidney Development and Polycystic Kidney Disease
… coupled with ex vivo culture of embryonic kidneys with defined media allowed us to determine which metabolic pathways were affected by the deficit of Lkb1. Our results revealed that Lkb1 mutant cells and embryonic kidneys require glutamine for growth while wild-type cells and kidneys did …
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Balancing Renewal and Differentiation of Progenitor Cells in the Developing Kidney
Mammalian kidneys perform the important function of blood filtration. All the filtered wastes are concentrated into urine and excreted from the body. The kidney performs these functions through individual functional units called nephrons. While nephron number may decrease during one's lifetime (due …
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Effect of renal replacement therapy on acute kidney injury in sepsis patients
… of sepsis is organ failure, notably in the kidneys, lungs, liver, and brain. In the case where the kidneys fail, renal replacement therapy (RRT) may be performed in order to sustain the functionality of the kidneys and overall ameliorate patients' outcomes. The goal of this work is to …
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The Effect of Nephrotomy on Renal Function and Morphology in Normal Cats
… cat 2, 28 and 84 days post-operatively. Both kidneys were measured sonographically 28 and 86 days postoperatively and an ultrasound-guided biopsy of each kidney was obtained 86 days postoperatively. Results: No significant differences in mean GFR and kidney size of the operated versus …
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The role of Rnd3 in kidney morphogenesis and function
… in the cortex in 5-month-old adult Rnd3tm1b+/- kidneys. A significant upregulation in Pkd1 and Pkd2 expression was also observed in adult Rnd3tm1b+/- mice. The kidneys of aged 9-month-old Rnd3tm1b+/- mice presented with multiple cysts in the cortex, mimicking moderate-to-severe ADPKD. The …
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