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Showing 1 to 20 of 27 for “"Kidney development"”.
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The Localization of β-catenin During Xenopus Kidney Development: A Look into β-catenin's Role in Kidney Development
… cell communication system that drives embryonic development. Wnt pathways regulate a variety of developmental processes, including cell migration, proliferation, and fate determination. Dysregulation of Wnt signaling can lead to developmental disorders and diseases. The primary Wnt trajectory: …
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The Role of Daam1 In Kidney Development
<p>Kidneys, like most organs in our bodies, consist of a network of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric …
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The Role of Daam1 In Kidney Development
<p>Kidneys, like most organs in our bodies, consist of a network of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric …
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The Novel Role of Dnmbp In Kidney Development
<p>Congenital anomalies of the kidney and urinary tract (CAKUT) accounts for nearly one-fourth of all birth defects and more than 40% of pediatric end-stage renal disease, yet only 10-20% of CAKUT cases have a known monogenetic cause. Human kidneys are composed of up to a million epithelial tubules …
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A Novel Role For Dyrk1A In Kidney Development
<p>Congenital anomalies of the kidney and urinary tract (CAKUT) are a leading cause of pediatric kidney failure and encompass a wide range of structural malformations resulting from defects in morphogenesis. CAKUT occur in ∼1/500 live births and with an average wait time of 3-5 years for a kidney …
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Targeting Glutamine Metabolism in Kidney Development and Polycystic Kidney Disease
Polycystic kidney disease is a hereditary disorder characterized by the progressive manifestation of numerous fluid-filled sacs, known as cysts, within the renal epithelia. The enlargement of the cysts causes the gradual replacement of normal kidney parenchyma which leads to impairment of renal …
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Investigating Vascular Patterning and Regression in Kidney Development and Organoids
Pages 74-127 are misnumbered as pages 75-128.
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Dysregulation of Meox2 Following Wt1 Mutation In Kidney Development and Wilms Tumorigenesis
<p>Wilms tumor (WT) is a childhood tumor of the kidney and a productive model for understanding the role of genetic alteration and interactions in tumorigenesis. The Wilms tumor gene 1 (<em>WT1</em>) is a transcriptional factor and one of the few genes known to have genetic alterations in WT and …
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The Fate and Behavior of Ret-expressing Tip Cells in Kidney Development
The mammalian kidney is a complex structure composed of many highly differentiated cell types. The spatial distribution of these cells, however, emerges from elaboration of an earlier program of epithelial and mesenchymal interactions in which a tubular epithelium, the ureteric bud, undergoes …
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Engineering Complex Kidney Structures for Disease Modelling, Drug Testing, and Studying Kidney Development
Although existing kidney tissue engineering systems and cell-based strategies favoured significant advances in the field, they cannot reproduce the organ’s complex architecture. This prevented the use of these tissues in studying kidney development realistically, modelling diseases, and …
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Wnt9b Signals Through Two Distinct Pathways to Regulate Progenitor Maintenance, Differentiation and Morphogenesis During Kidney Development
The development of the kidney is dependent upon reciprocal interactions between the ureteric bud epithelium and a mesenchymal progenitor population known as the metanephric mesenchyme. Signals from the ureteric bud cause a subset of the progenitors to differentiate into tubules while the remainder …
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Modeling Renal Anomalies Associated with Li-Fraumeni Patients: A Novel Role for p53 in Kidney Development
… patients have an increased risk of developing kidney, stomach, colon, pancreas, esophagus, lung, and gonadal germ cell cancers. Prior studies indicate that <em>p53 </em>is involved in kidney development. However, there is no confirmed link between Li-Fraumeni <em>TP53 </em>patient mutations and …
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The Role of the Ca2+-dependent protein kinase, CaMK-II, in Heart and Kidney Development in the Zebrafish, Danio rerio
… induce cardiac arrhythmias and heart failure. Developmental roles for CaMK-II are not as well understood since mouse knockouts are embryonic lethal. Therefore the identification of other vertebrate CaMK-II genes will add to our understanding of development. Zebrafish encode seven catalytically …
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Investigating the control of epithelial polarisation in human kidney organoids
… of adult organs, and failures in either the development or maintenance of these structures is the basis of many adult pathologies, such as polycystic kidney disease. One of the key mechanisms of tube formation during development is so-called *de novo* acquisition of polarity, where initially …
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Advanced in vivo imaging of the interactions between vascular and renal development in the zebrafish pronephric kidney
… disease is partly caused by the reactivation of developmental programmes. By unravelling the mechanisms that drive kidney development and function, it may be possible to gain novel insight into remodelled kidney states that are linked to disease. In this study, we have investigated the interplay …
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Balancing Renewal and Differentiation of Progenitor Cells in the Developing Kidney
Mammalian kidneys perform the important function of blood filtration. All the filtered wastes are concentrated into urine and excreted from the body. The kidney performs these functions through individual functional units called nephrons. While nephron number may decrease during one's lifetime (due …
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Characterisation of the role of VPS33B in Vesicular trafficking in polarised Epithelial cells.
… are essential for epithelial function and organ development but the molecular pathways determining the biogenesis of polarised membranes are not fully characterised. Mutations in VPS33B, a Sec1-Munc18 protein, account for 75% of ARC patients. Reduced expression of VPS33B at both the RNA and …
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Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour
… Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are classified as high risk tumours. According to the SIOP2001 protocol …
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Analysis of the Function of Megf7 During Development
… regulator of tissue patterning during embryonic development. Prior to this work, the function Megf7 had largely been unknown. Eight distinct mutations in Megf7 were introduced into mice in order to facilitate a functional analysis of Megf7. The Megf7EC Stop mutant, which has a premature stop …
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Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
… tissue-specific gene expression in the liver, kidney, pancreas, and other epithelial organs. During kidney development, HNF-1Beta is expressed in renal collecting ducts and all segments of the nephron. Mutation of HNF-1Beta causes maturity-onset diabetes of the young type 5 (MODY5) and kidney …
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