Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Kidney Cancer"”.
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Chemoprevention in Kidney Cancer
… studies that explore the role of statins in kidney cancer. Furthermore, I evaluate the potential for different interpretations from the same data depending on the method of classifying medication use. Methods: The first study was a population-based case-control study evaluating the …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… cell carcinoma (ccRCC), the most common form of kidney cancer. In particular, overexpression of HIF2alpha has been intimately linked to ccRCC molecular pathogenesis. Here, we report that HIF2alpha overexpression leads to Akt-mediated hyperactivation of Hdm2, resulting in decreased activity of p53 …
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Studies on renal progenitor cells and kidney cancer
Kidney cancer and renal injuries affect millions of people in the world resulting in high patient morbidity and mortality, as well as one of the most extensive medical costs for society. Upon renal injury the kidney has an endogenous ability to repair damaged tubules and restore kidney function, …
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Understanding missed diagnostic opportunities in bladder and kidney cancer
Background Bladder and kidney cancer are among the ten most commonly diagnosed cancers in the UK every year. Delayed diagnosis is associated with poorer survival and patient reported outcomes. Bladder and kidney cancers pose diagnostic challenges as presenting symptoms such as haematuria and lower …
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Molekuliniai ir klinikiniai inkstų vėžio prognozės rodikliai /
… safety of active surveillance of small kidney tumors. It identifies the prognostic factors of aggressive kidney cancer that can help the urologist choose the right treatment tactics.The work evaluated the predictive value of epigenetic markers in determining aggressive forms of kidney …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
Kidneys are important target organ for oxidative stress mediated injury and oxidative stress has been suggested as a common pathway shared by multiple risk factors of kidney cancer. But there is no experimental evidence to show direct role of oxidative stress in kidney cancer. In this study, our …
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Diagnostic and prognostic DNA methylation biomarkers of renal clear cell carcinoma /
… carcinoma (ccRCC) is the most common type of kidney tumor with the highest incidence rates in Lithuania. CcRCC is characterized by the highest mortality rate of genitourinary cancers, therefore, new diagnostic and/or prognostic biomarkers are urgently needed. Considering this, the current …
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SOSTDC1: A BMP/Wnt Dual Antagonist in Breast and Renal Cancers
… A BMP/WNT DUAL ANTAGONIST IN BREAST AND RENAL CANCERS Dissertation under the direction of Suzy V. Torti, Ph.D., Associate Professor of Biochemistry The bone morphogenetic protein (BMP) pathway and the Wnt pathway are signaling networks associated with carcinogenesis. BMPs and Wnts are powerful …
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Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… (localised and locallyadvanced) renal cancer. Renal cancer is the deadliest urological malignancy with a widening gap between incidence and mortality, which highlights the need to review the current guidelines. In particular, early-stage renal cancer is to be looked into as it is …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
Kidney cancer is the 14th most common cancers in the world, among which clear cell renal cell carcinoma (ccRCC) is the most common subtype. VHL inactivation is the most common mutation seen in ccRCC with more than 90% of tumours had clonal disruption of the VHL pathway. Although it is the initial …
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Biological activity of palmitoylcarnitine in prostate cancer
… in diabetes mellitus type II, obesity and kidney cancer. Certain dietary intervention studies have been shown to reduce serum and urinary levels of acylcarnitines. It was shown that palcar accumulates in prostate cancer tissue, possibly indicative of the metabolic changes associated with …
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
… carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases. Inactivating mutations of VHL lead to stabilisation of HIF2α which in turn drives the expression of multiple target …
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Ambient ionization - mass spectrometry: Advances toward intrasurgical cancer detection
… measurements, specifically intrasurgical cancer detection. The molecular differences between normal and cancerous tissue were detected via direct tissue analysis in vitro by touch spray ionization (TS) or by analyzing sectioned or smeared tissue using desorption electrospray ionization …
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Inkstų vėžys Lietuvoje: sergamumo ir mirtingumo pokyčių analizė /
… of the study: To review epidemiology of renal cancer in Lithuania during the period 1998 – 2012. Tasks of the study: 1. To estimate the changes of renal cancer incidence in Lithuania in 1998 – 2012. 2. To estimate the changes of renal cancer incidence in Lithuania depending on stage of the …
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Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour
… Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are classified as high risk tumours. According to the SIOP2001 protocol …
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Hypoxia regulated pathways in urological malignancies
Introduction: Kidney Cancer accounts for approximately 2% of all new cancer diagnoses in<br/>the UK each year. Patient survival has improved over the past few decades; however the<br/>mechanisms of this are yet to be fully elucidated. Hypoxia inducible factor isoforms, HIF-1 and<br/>HIF-2, are …
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RNA sequencing for the study of splicing
… By analysing healthy and tumor samples from kidney cancer patients, I show that most of the detected splicing alterations do not lead to big changes in the relative abundance of major transcripts, at least in a recurrent manner. In addition, I introduce a framework to visualise the most …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
… carcinoma (ccRCC), the most common subtype of kidney cancer, is characterised by biallelic inactivation of the von Hippel-Lindau (*VHL*) tumour suppressor gene, and inherited loss-of-heterozygosity of *VHL* underlies the eponymous hereditary cancer syndrome. The *VHL* protein product, pVHL, is …
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Integration of Multi-Platform High-Dimensional Omic Data
… with smoking status and survival using The Cancer Genome Atlas (TCGA) datasets. The simulation studies demonstrate the superior performance of SIFORM in terms of biomarker detection accuracy. In lung cancer applications, SIFORM identifies many biomarkers that belong to key pathways for lung …
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Development and application of a high throughput cell based assay to identify apoptosis inducing proteins, and functional characterization of the candidate Vacuole Membrane Protein 1 (Vmp1)
… that VMP1 mRNA is differentially expressed in cancer, acute pancreatitis and kidney ischemia and that the overexpressed protein is localized to the Endoplasmic reticulum. But the function of this protein and its role in cancer and other diseases was previously unknown. In this study I show that …
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