Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Key cell"”.
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Human intestinal cells across space and time
Cells of the human intestinal tract undergo dynamic changes from development to adulthood and in response to environmental stimuli. Recent advances in high-throughput profiling of cells using transcriptomic approaches have vastly expanded the catalogue of cells that are found across the human body. …
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Separase cleaves the kinetochore protein Meikin to direct the meiosis I/II transition
To generate haploid gametes, meiotic cells must undergo two consecutive rounds of chromosome segregation without an intervening gap phase. Importantly, because homologous chromosomes are segregated in meiosis I, but sister chromatids are segregated in meiosis II, this requires a dramatic rewiring …
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Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
… signaling pathways that are critical for making key cell fate decisions in normal cells. Understanding how these pathways operate under normal circumstances, therefore, is crucial for comprehensive understanding of tumorigenic process. With Myc and E2F pathways being central components for …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
… (ROS) and excessive proliferation of tumour cells. Many treatments are available or under investigation as anticancer therapeutics such as cell therapy, immunotherapy, gene therapy and nanotechnology-based strategies but they all have severe complications and side effects that limit their …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
… (ROS) and excessive proliferation of tumour cells. Many treatments are available or under investigation as anticancer therapeutics such as cell therapy, immunotherapy, gene therapy and nanotechnology-based strategies but they all have severe complications and side effects that limit their …
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
… which Six1 regulates the expression of MyoD, a key myogenic gene, in muscle stem cells. Furthermore, loss-of-function of this protein, mediated by RNA interference, has implicated Six1 as essential towards normal myogenic differentiation. However, beyond Six1 and its involvement towards …
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Development of monoclonal antibody cell culture processes and antibody characterisation
… antibody production process, including upstream cell culture, downstream purification and analytical characterisation. A CHO-DP12 cell line engineered for anti-IL-8 mAb expression and a cNIST mAb-producing CHO cell line were employed to investigate key cell culture process parameters. Upstream …
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Epidermicin NI01 and human β-defensin 2 as modulators of macrophage subset responses
… is known about their effects on macrophages, a key cell population in inflammatory responses that mediates communication between innate and adaptive immunity. Macrophages are a pleiotropic cell population composed of different subsets that orchestrate diverse stages of inflammation with roles …
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alpha-Actinin-4 and the podocyte: Implications for focal segmental glomerulosclerosis
… result from damage to glomerular epithelial cells called podocytes, a key cell type involved in glomerular filtration. Mutations in the ACTN4 gene, encoding an actin-crosslinking protein, are causative of late-onset familial FSGS in humans. We have developed a mouse model of FSGS by …
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Development of a model to explain the effect of variable membrane compliance on single molecule adhesive bond force
… between adhesive membrane receptors and extracellular matrix (ECM) molecules is believed to regulate key cell functions, such as growth, apoptosis, motility, and mechanotransduction. From a clinical perspective, understanding the mechanics of cell-matrix bonds may be key to unraveling the …
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The Cellular and Molecular Properties of Flavinoids in Prostate Cancer Chemoprevention
… flavonoids, their molecular effects on cell cycle and related proliferation and survival pathways, and their chemopreventive properties in a murine model of prostate carcinogenesis. We identified several novel flavonoids with potent anti-proliferative effects in human prostate cancer …
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Lack of Inflammatory Response in Mouse Embryonic Cells to Listeria Infection
… the early embryo. Recent research has shown that key cell types within mouse blastocysts, including embryonic stem cells (ESCs) and trophoblast stem cells (TSCs), exhibit remarkable resilience against the cytotoxic effects associated with viral infections and embryotoxic cytokines, such as TNFα …
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Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
… by preventing APC/C-mediated degradation of two key cell cycle regulators, cyclin B and securin. The MCC is composed of BubR1, Cdc20 and Mad2, and while their assembly is an intrinsically very slow process, in cells it is catalytically activated. Recent work points towards hierarchical …
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Somatic Mutations in Primary Sjögren’s Syndrome
… and lacrimal glands, which is mediated by immune cell infiltration into these tissues. As cells age and divide, they accumulate mutations and structural changes in DNA. These somatic mutations are often inconsequential but sometimes result in cell death, cancerous transformation, or other …
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Analysis of the Role of the Transcription Factor-C/ebpbeta in Implantation
… and differentiation of uterine stromal cells. The molecular pathways underlying this hormonally induced cellular transformation, an essential prerequisite for embryo implantation, are poorly understood. We previously identified the transcription factor C/EBPbeta as a target of steroid …
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Analysis of the role of the transcription factor-C/EBPβ in implantation
… and differentiation of uterine stromal cells. The molecular pathways underlying this hormonally induced cellular transformation, an essential prerequisite for embryo implantation, are poorly understood. We previously identified the transcription factor C/EBPβ as a target of steroid …
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Lineage-Specific Phenotypic Abnormalities in iPSC-Derived Smooth Muscle Cells from Type-I Loeys-Dietz Syndrome
… develop at the aortic root, where smooth muscle cells (SMCs) from two distinct embryonic origins – the lateral mesoderm (LM) and neural crest (NC) – are intermingled. SMCs are hypothesised to be the key cell type contributing to TAA development. However, only LM-SMCs showed abnormal …
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Insights into the regulation of the CRL4D̳T̳L̳ ubiquitin ligase
The eukaryotic mitotic cell cycle is a strictly ordered process by which cells accurately duplicate their genome and divide into two. Ubiquitin-mediated degradation of key cell cycle regulators ensures that the cell cycle phases progress in a unidirectional and orderly manner. Cullin E3 ubiquitin …
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The Paradoxical Roles of Cell Death Pathways in Immune Cells
Cell death plays a vital role throughout the immune response, from the onset of inflammation to the elimination of primed T cells. Understanding the regulation of cell death within immune cells is of vital importance to understanding the immune system and developing therapies against various …
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In vitro evaluation of Ultraviolet Radiation (UVR) exposure of the Retinal Pigmented Epithelium (RPE) and its relevance to Age-Related Macular Degeneration (AMD)
… consensus for or against it playing a role. A key reason for this is a lack of foundational research into the response of living retinal tissue to UVR in regard to AMD-specific parameters of tissue function. To this end, we sought to explore the response of cultured retinal pigmented epithelium …
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