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Showing 1 to 2 of 2 for “"Ketone alpha alkylation"”.
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Nucleophilic Addition to Azoalkenes; Diastereoselective Synthesis of β-Hydroxy Ketones and β,γ-Fused γ-Lactams
The α-alkylation of ketones and their derivatives by the addition of their corresponding enolates to alkyl halides is a fundamental synthetic transformation, but its utility is limited because the key bond-forming step proceeds in a bimolecular nucleophilic substitution fashion. Here in the first …
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Asymmetric α-Alkylation of Acyclic Ketones Utilizing Chiral Nonracemic N-Amino Cyclic Carbamate Hydrazones
Asymmetric variants of ketone α-alkylation are highly important given that numerous natural products, drugs, and related compounds exist as α-functionalized ketone or derivatives thereof. A method for asymmetric α-alkylation of ketones using N-Amino cyclic carbamate (ACC) chiral auxiliaries is …