Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Ketogenic diet"”.
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Ketogenic Diet is Protective During Endotoxin-Induced Lung Injury
… caloric intake. However, the impact of dietary interventions such as the ketogenic diet remains poorly understood in septic ARDS. The ketogenic diet, characterized by a high-fat and low-carbohydrate content, has been shown to exhibit anti-inflammatory properties and satisfactory safety …
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A KETOGENIC DIET AND PHYSICAL ACTIVITY’S EFFECT ON PERIPHERAL NERVE FUNCTION
… mechanical sensitivity induced by a high fat diet. Utilizing a genetic rat model of differing intrinsic aerobic levels, our results show that genetic differences that result in varied metabolism alters peripheral nerve function and sensation. Highlighting the importance of metabolism, our …
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Κετογονική δίαιτα και καρκίνος του μαστού: Μια συστηματική ανασκόπηση / Ketogenic diet and breast cancer: A systematic review
Ο καρκίνος του μαστού αποτελεί τον συχνότερο καρκίνο στις γυναίκες και μία από τις κύριες αιτίες θανάτου παγκοσμίως, επιβαρύνοντας σημαντικά και τα συστήματα υγείας. Παράγοντες όπως η ηλικία, το στάδιο της νόσου, η έκφραση HER2-Neu και η κατάσταση των ορμονικών υποδοχέων αποτελούν γνωστούς …
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IMPACT OF KETOGENIC DIET TREATMENT IN GLUT1 DEFICIENCY SYNDROME: DISCOVERY OF MOLECULAR MECHANISMS RESPONSIBLE FOR PHENOTYPE CHANGES IN BOTH PEDIATRIC AND ADULT PATIENTS
… farmaco-resistente e disturbi del movimento. La dieta chetogenica (KD) si è dimostrata promettente nel trattamento della GLUT1-DS, come fonte energetica alternativa al glucosio. Sebbene molti aspetti clinici e biochimici della malattia siano stati ampiamente investigati, alcune aree di ricerca …
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EXPANSION OF CLINICAL PHENOTYPE AND USE OF KETOGENIC DIET IN RARE GENETIC CONDITIONS: GLUCOSE TRANSPORTER TYPE 1 DEFICIENCY SYNDROME AND SCN8A-RELATED DISORDERS
… as well as to evaluate the efficacy of the ketogenic diet (KD) as a treatment. Regarding GLUT1-DS, data were collected at the Italian reference centre “Vittore Buzzi” Children’s Hospital, the main site of the doctoral research, in collaboration with IRCCS “Carlo Besta”, both located in …
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Framing, Advice-Seeking, and Medical Trust in the r/Keto Community: An Analysis of the Medical Flair on r/Keto
<p>First created in 1921, the ketogenic diet was used as a medical intervention for children suffering from severe epilepsy. However, in recent years, this highly restrictive diet has gained mainstream popularity for a number of illness management, wellness, and weight loss uses. Despite its rise …
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Alterations of High-Energy Brain Metabolites Across Multiple Neurodegenerative Disorders
… Down syndrome, and HIV-1 dementia and that dietary treatments could enhance energy reserves and protect against neurodegenerative disease. For rodent studies, I utlilized a high-energy head focused microwave irradiation system to kill animals but most importantly to snap-inactivate all …
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Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
… We have also found that the metabolic therapy, ketogenic diet (KD), significantly reduces seizures and prolongs lifespan in KO mice. Markers of inflammation activated in toll-like receptor 4 (TLR4) pathway are associated with apnea and respiratory failure, therefore we determined whether an …
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Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling
… clinical significance using customized ketogenic diets, measurements of systems physiology, evaluation of substrate utilization using 13C-edited proton nuclear magnetic resonance, measurements of mitochondrial bioenergetics, and in vivo high-resolution echocardiographic quantification of …
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Medicalised Ketogenic Therapy Practice
… bringing necessary disruption to medicalised ketogenic therapy delivery practice, nationally and internationally. The impact I want is the opportunity for practitioners to change to an individualised patient care model by applying technology and associated artificial intelligence. My purpose …
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The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
… prevented in DKO mice fed a high saturated fat diet for 30 weeks. As expected, DKO mice fed a high fat diet had improved glucose tolerance, decreased adiposity, and were euglycemic due to reduction in the rate of gluconeogenesis. Like chow fed DKO mice, high fat fed DKO mice were unusually …
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Identifying a role for the scaffolding protein IQGAP1 in liver health and disease
… fast and that deletion of IQGAP1 blunts the ketogenic response to fasting and ketogenic diet feeding, which is associated with impaired PPARα activation and hyperactive mTORC1 signaling. Furthermore, in chapter 4 I show that IQGAP1 is upregulated at a transcriptional level by bile acid …
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Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders
This dissertation investigates the effects of the ketogenic diet (KD) on adipose tissue (AT) metabolism and renin-angiotensin system (RAS) function and potential implications for other tissues, including lung, heart and skeletal muscle. In the first study, it was demonstrated that despite …
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Investigation of Tanycytes and Orexin Neurons in the KCNA1-Null Mouse Model of Epilepsy
… or whether metabolic interventions such as the Ketogenic Diet (KD), known to reduce seizure frequency, have a restoring effect on tanycytes. We hypothesized that SRS impacts the tanycytic protein expression in the Kcna1-null mouse model (the SRS group) and the KD has a restoring effect. We …
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MODULATION OF TASTE PERCEPTION AS A POSSIBLE STRATEGY IN OBESITY TREATMENT: NEW PERSPECTIVES FOR PRECISION NUTRITION
… include non-pharmacological treatments such as dietary therapy, also combined with drug therapy, and bariatric surgery as first-line treatments. However, it is becoming increasingly important to find new management strategies, especially from a nutritional perspective. These strategies can …
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The gut microbiome: a contributing mechanism to the anti-seizure effect of topiramate
… include surgery, vagus nerve stimulation, or diet alterations such as the ketogenic diet. Due to the invasiveness of surgeries, difficulty to maintain specialty diets, or lack of effectiveness of these treatments in some patients, additional therapies are needed. The gut-brain axis is a …
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The host response to cancer and cancer-associated cachexia
… chapter of my thesis, I analyse the usage of ketogenic diets (KD) containing high levels of fats as adjuvant therapies in end-stages of cancer that are associated with cachexia. Metabolism of fats through non-enzymatic lipid peroxidation is a recognized source of highly reactive and mutagenic …
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Επίδραση διάφορων δίαιτων απώλειας βάρους στο οξειδωτικό στρές και στους αντιοξειδωτικούς μηχανισμούς παχύσαρκων παιδιών
Εισαγωγή: Η παχυσαρκία στα παιδιά και στους εφήβους αποτελεί ένα αυξανόμενο παγκόσμιο πρόβλημα δημοσίας υγείας επιφέροντας αύξηση στο οξειδωτικό στρες με συνακόλουθες βραχυπρόθεσμες και μακροπρόθεσμες μεταβολικές και καρδιαγγειακές επιπλοκές. Παρόλο, που η πρόληψη της παιδικής παχυσαρκίας είναι …