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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Ketogenesis"”.
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Hepatic acetogenesis and ketogenesis in neonatal swine
… unlike previously-studied neonates, enhanced ketogenesis does not characterize the metabolism of the newborn pig. This apparent idiosyncracy of piglet metabolism prompted a series of studies examining development and regulation of ketogenesis in piglets, and the physiological implications of …
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Carnitine and Altered Lipid Metabolism in Iron-Deficient Rats Pre- and Postweaning (Ketogenesis)
… long-chain fatty acids away from oxidation and ketogenesis into triglyceride synthesis increasing triglyceride levels in serum and liver. The rationale for carnitine involvement is based on two facts: (1) carnitine synthesis in vitro requires ferrous iron; and (2) carnitine is required to …
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Impaired ketogenesis is implicated in intestinal stem cell function and epithelial regeneration in ulcerative colitis
… of fatty acid metabolism pathways, particularly ketogenesis, with HMGCS2 as the top downregulated gene in UC ISCs. HMGCS2, the rate limiting mitochondrial matrix enzyme in the ketogenesis pathway, producing βHB, which alongside providing metabolites for the mitochondrial tricarboxylic acid TCA …
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The role of mammalian target of rapamycin complex 1 in hepatic physiology and disease
… in old age including fatty acid catabolism and ketogenesis. We find this aging-dependent process is mediated by mTORC 1, and thus loss of mTORC 1 function throughout the adult life of the animal prevents the aging induced decrease in hepatic ketogenesis. As such, pharmaceutical inhibition of …
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Peroxisomal beta-oxidation of fatty acids in neonatal swine
… from $\beta$-oxidation that is not coupled with ketogenesis or that is coupled to a limited ketogenesis. A substantial POX activity was present in the three tissues of piglets immediately after birth. POX was markedly induced in liver and heart, but not kidney or muscle, when neonatal pigs were …
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… to recovery from ischaemia/reperfusion injury. Ketogenesis was found to occur in the ischaemic heart, and was not specifically dependent upon either fatty acid or glucose oxidation. Its inhibition resulted in improved recovery of contractile function following ischaemia/reperfusion, suggesting …
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Metabolic Regulation by Fibroblast Growth Factor 21
… to ketone bodies through a process known as ketogenesis. Here, I show the effects of FGF21 as a fasting hormone that is expressed in liver and contributes to the regulation of adipose tissue and hepatic ketogenesis during the fasted state. Using in vitro and in vivo methods to investigate the …
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Hepatic gene networks due to the trans-10, cis-12-conjugated linoleic acid supplementation in growing male mice
… VLDL assembling/secretion (Mttp and Cideb), ketogenesis and utilization (Hmgcs2 and Bdh1), fatty acid oxidation (Acox1), glyceroneogenesis (Pck1 and Pdk4). The results suggest that the increased liver weight in response to trans-10, cis-12-CLA may be due to increased fatty acid uptake, …
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Ketogenic Diet is Protective During Endotoxin-Induced Lung Injury
… (BHB), the primary metabolite of ketogenesis, before or after the onset of septic ARDS has also been shown to reduce pulmonary edema and lung inflammation, implying a potential molecular mechanism for the ketogenic diet-mediated lung protection. These findings display that the …
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The Role Of Crebh In Hepatic Energy Regulation Under Metabolic Stress
… genes involved in lipolysis, FA oxidation, and ketogenesis by activating fibroblast growth factor 21 (FGF21), a hepatic hormone that regulates whole-body energy homeostasis. Gain- and loss-of-function analyses indicated that CREBH and PPARA regulate each other for their expression. Activated …
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Post-exercise ketosis in non-diabetic subjects
… subjects. The results indicate that ketogenesis is not the result of gluconeogenesis, nor of a low insulin/glucagon (+ growth hormone) ratio in the blood. It is concluded that low levels of glycogen, or of a metabolic intermediary of glycogen metabolism (such as glucose-1-phosphate, …
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The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
… glycogenolysis, and later by gluconeogenesis and ketogenesis. Additionally, animals alter daily behavioral patterns to seek food, but eventually reduce energetically costly activities (growth, reproduction, locomotion). Little is known about the mechanisms that orchestrate and coordinate these …
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3-Hydroxy-3-methylglutaryl-coenzyme A lyase: investigation of cysteines mediating intersubunit disulfide formation and regulation by thiol/disulfide exchange and discovery of an extramitochondrial homolog
… and acetyl-Coenzyme A, a key reaction in ketogenesis and leucine catabolism. Previous work prompted the hypothesis that in the absence of reductant, cysteine 323 forms a disulfide bond with cysteine 323 on the adjacent monomer, blocking the substrate's access to the active site which …
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Regulation of Highly Unsaturated Fatty Acid Metabolism
… with mitochondrial fatty acid oxidation and ketogenesis in pigs, indicating that PPARalpha mediates the induction of these genes. In contrast to rats and mice, neither noticeable induction of genes for peroxisomal or microsomal fatty acid oxidation nor significant hepatomegaly was observed in …
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Aspects of hormonal regulation of hepatic carbohydrate and lipid metabolism
… lipogenesis,<br/>glycolysis, gluconeogenesis and ketogenesis is considered.
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IMPORTANCE OF SUPPLYING DAIRY COWS WITH ESSENTIAL FATTY ACIDS (EFA) AND CONJUGATED LINOLEIC ACIDS (CLA) DURING THE TRANSITION PERIOD ON METABOLISM AND HEALTH
Ketogenesis and steatosis are common sequelae of the severe mobilization of fat reserves necessary at the onset of lactation when the energy expenditures for milk and maintenance exceed the energy provided by voluntary feed intake in dairy cows. This situation along with a common state of systemic …
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Influence of feed efficiency ranking and maternal nutrition on gut microbiome, metabolome, and transcriptome in beef and dairy cattle
… M-eff cattle upregulated VFA absorption and ketogenesis in ruminal epithelium, underscoring greater energy production in M-eff cattle than L-eff cattle. These might have helped M-eff cattle to maintain the same level of growth performance as L-eff group while consuming less dry matter intake …
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An In silico Liver: Model of gluconeogenesis
An in silico liver was developed in attempt to represent the in vivo state of the fasted liver. It featured two conceptual models. The first one represented carbohydrate metabolism of the human liver, which included the heterogeneous nature of the liver by incorporating spatial variation of key …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… normalize glycemia and alternative mechanisms as ketogenesis were aberrantly activated to face with energy demand. In addition, AIP patients with clinically stable disease or highly porphyrins’ excreters may develop similar metabolic disturbances, which may alter the response to glucidic therapy. …