Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Kdm6a"”.
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CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
Kdm6a is an X-linked gene encoding a lysine demethylase involved in epigenetic regulation of gene expression. It catalyzes the demethylation of histone H3 lysine-27, counteracting the function of Polycomb Repressive Complex 2 (PRC2). Kdm6a plays a key role in transcriptional activation of genes …
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Regulation of Chromatin Landscape on and by the Human Sex Chromosomes
… and Xi-silent genes. A key Xi-expressed gene, KDM6A, encodes an H3K27me3 demethylase—enabling Xi to impact chromatin structure genome-wide. Its Y homolog, UTY, is thought to encode a catalytically dead enzyme. However, we demonstrate that Xi and Y copy number-dependent changes to H3K27me3 …
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Metilación de histonas y fisura labio-palatina: asociación e interacción de variantes genéticas
… y demetilación de histonas (EZH2, KDM1A, KDM6A, KDM6B, KMT2D, MECOM, PHF8, PRDM16, PRMT1, SETDB1, WHSC1) y el riesgo de FL/PNS en población chilena. La hipótesis planteó que variantes de estos genes representan elementos de riesgo para la aparición de fisuras labio/palatinas no …
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Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
… while mutations in the histone demethylase KDM6A generate very large areas of mutant epithelium in aged humans. Further, targeted sequencing revealed dramatic expansion of KRAS-mutant clones in histologically normal colon. Patches may arise from crypt fission and fusion events. Using a …
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Identifying genetic variation in candidate genes for heat stress and association thereof with growth performance in dusky kob (Argyrosomus japonicus)
… SNPs across candidate genes igfbp2a, hsp90b and kdm6a, and three haplotypes of igfbp2a that were significantly associated with differential growth performance. Breeding schemes may incorporate these data with marker assisted selection to allow for selection of broodstock individuals early in …
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TARGETING NEUROINFLAMMATION TO RELIEVE FABRY DISEASE NEUROPATHIC PAIN:EFFICACY OF PROKINETICIN SYSTEM ANTAGONISM AND MICROGLIAL INHIBITION
… (GFAP e Iba1) e, nei DRG, enzimi epigenetici (KDM6A/B) e PPARγ, un mediatore antinfiammatorio. IWestern Blot e l’immunoistochimica sono stati eseguiti per valutare l’espressione proteica di PK2, GFAP e Iba1 nell’intestino e nel sistema nervoso centrale. Le analisi biochimiche hanno confermato …