Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Kappa Opioid Receptor"”.
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
<p>The opioid system, comprised mainly of the three opioid receptors (kappa, mu and delta) and their endogenous neuropeptide ligands (dynorphin, endorphin and enkephalin, respectively), mediates mood and reward. Activation of the mu opioid receptor is associated with positive reward and euphoria, …
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The role of the kappa opioid receptor system in forebrain dependent associative learning
The opioid receptor system has been shown, through various lines of evidence, to be involved in pain processing, addiction, and learning and memory. It has been previously established that the mu opioid receptor (MOR) is intimately involved in the acquisition and consolidation of memories. While …
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Mechanisms Underlying the Adverse Consequences of Stress: A Role for the Dynorphin/Kappa Opioid Receptor System, p38α MAPK, and the Serotonin Transporter
… event, the dynorphins, a family of endogenous opioids, are released and subsequently bind to and active the kappa opioid receptor (KOR), but how the dynorphin/KOR system mediates these adverse behaviors remains unknown. My dissertation sought to further our understanding of the role of the …
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Development of Nanoprobes for the Biological Imaging Using Positive Charged Quantum Dots and Upconversion Nanoparticles
… molecules including antibody for detection of kappa opioid receptor, small peptide for detection of integrin ανβ3 and oligonucleotides for the detection of influenza virus. These functionalized NPs were useful to visualize the endocytosis of kappa opioid receptor in live cell, to acquire in …
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DESIGN, SYNTHESES, AND BIOLOGICAL EVALUATION OF 14-N-SUBSTITUTED NALTREXONE DERIVATIVES AS OPIOID RECEPTOR LIGANDS
… ingredient of opium, and other clinically useful opioid analgesics all mediate their effects through activating the mu opioid receptor. Studies involving the mu opioid receptor knockout mice showed that the interaction with the mu opioid receptor is also responsible for many notorious side effects …
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Advances in structure and small molecule docking predictions for crystallized G-Protein coupled receptors
… protein-ligand interaction for G-Protein coupled receptors: structure predictions of the flexible loop domains and docking into these receptors. The prediction of loop structure has been long worked on in the context of native, globular proteins. In this work it is extended to transmembrane …
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Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… the first that is not an agonist of the 5-HT2A receptor. It is a potent, selective agonist of the Kappa opioid receptor (KOR). The aim of our current research is to complete the total synthesis of Salvinorin A, then to synthesize novel analogs not attainable by semi-synthetic methods. The region …
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Synthesis towards Salvinorin Scaffold to Develop a Potential Pain Therapeutic and Selective, Potent Kappa Opioid Ligands
… who have sought after traditional therapy, opioid analgesics. Particularly in patients with chronic pancreatitis, traditional therapy has failed to assist with pain management causing daily activity to be an even bigger challenge. Drugs like morphine or codeine, mu opioid agonists, have been …
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OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
… of the central nervous system (CNS) express opioid receptors, the role of the endogenous opioid system in CNS development remains poorly understood. Identification of opioid functions during brain maturation is particularly crucial in light of the increasing trend in opioid abuse and the use …
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Ligand-based drug design : I. conformational studies of GBR 12909 analogs as cocaine antagonists; II. 3d-QSAR studies of salvinorin a analogs as kappa opioid agonists
… techniques are applied when the structure of the receptor is unknown but when a series of compounds or ligands have been identified that show the biological activity of the interest. Generally, availability of a series of compounds with high activity, with no activity, and also with a range of …
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Molecular Regulation of Opioid Receptor Signaling
The varied behavioral effects of kappa opioid receptors (KOR) are mediated through different signaling cascades. KOR activation of G protein-dependent signaling results in analgesia, whereas the dysphoric effects are mediated by a different pathway involving G protein-coupled receptor kinase (GRK) …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. We found that conditional deletion of KOR from Slc6a4 (SERT)-expressing …