Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Kaposi's sarcoma"”.
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An evaluation of 99mTc-MIBI imaging of Kaposi's Sarcoma in AIDS patients
Thesis (Doctor in Technology: Radiography), Durban Institute of Technology, Durban, South Africa, 2006
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Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
… (HHV8) is the aetiological agent of all forms of Kaposi's sarcoma (KS). Seven major subtypes (A, B, C, D, E, F, Z) based on genetic variability of open reading frame (ORF)-K1, have been identified. Numerous studies point to differing tumorigenic and pathogenic properties of the HHV8 subtypes. The …
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Relationship of HHV8 serum levels and clinical features of Kaposi's sarcoma among patients in South Africa
Background. Kaposi's sarcoma is an AIDS-defining illness caused by Kaposi's Sarcomaassociated Herpesvirus (KSHV). The level of HIV immune suppression and extent of KSHV DNA determine the development of Kaposi's sarcoma. Common manifestations of Kaposi's sarcoma include skin and mucosa} involvement. …
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Molecular genetics and functions of Kaposi's sarcoma-associated herpesvirus glycoproteins in viral entry and virus-induced cell fusion
Kaposi’s sarcoma-associated herpesvirus (KSHV) is considered the etiologic agent of Kaposi’s sarcoma and several lymphoproliferative disorders. Recently, the full-length KSHV genome has been cloned into a bacterial artificial chromosome (BAC) and successfully recovered in 293 cells. The herpesviral …
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The reactivation of Kaposi's Sarcoma-associated Herpesvirus (KSHV) by SARS-CoV-2 in non-hospitalised HIV-infected patients
… of Human Immunodeficiency Virus (HIV) and Kaposi's Sarcoma Associated Herpes Virus (KSHV). SARS-CoV-2 co-infection with herpesviruses has been suggested to have an impact on acute and/or long-term disease progression by triggering their reactivation from latency. We have previously reported …
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Characterisation of Kaposi's sarcoma-associated herpesvirus (KSHV)-driven pathology and disease outcome in HIV infected South African patients
Kaposi's sarcoma-associated herpesvirus (KSHV), a gamma-herpesvirus with a particularly high seroprevalence in Sub-Saharan Africa (SSA), is the etiological agent of the endothelial tumour Kaposi's sarcoma (KS), the most common acquired immunodeficiency syndrome (AIDS)-related malignancy worldwide …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
Kaposi's Sarcoma-Associated Herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is a tumorigenic herpesvirus tightly linked with various human malignancies including Kaposi's Sarcoma, Primary Effusion Lymphomas (PELs), and Multicentric Castleman's Disease. Immunocompetent individuals infected with …
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Cloning and expression of a functionally active truncated N-glycosylated KSHV complement regulatory protein and immunohistochemical studies with the anti-KCP peptide antibody
Kaposi sarcoma herpes virus (KSHV) is a typical DNA virus that is associated with a number of proliferative diseases including Kaposi's sarcoma. The KSHV open reading frame (ORF) 4 encodes a complement regulatory protein (Kaposi complement-binding protein, KCP) that binds complement proteins and …
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Translational initiation controls localization and regulatory function of the gamma-herpesviral protein kaposin
Kaposi's Sarcoma Associated Herpesvirus (KSHV) or Human Herpesvirus-8 (HHV-8) is the most recently identified human gamma-2 herpesvirus and has been implicated in Kaposi's Sarcoma (KS) and primary effusion lymphoma (PEL). At the right end of the genome KSHV encodes the complex kaposin locus, which …
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The impact of EPHA2 polymorphism on KSHV infectivity and KS prevalence among HIV/AIDS patients in South Africa
Kaposi's Sarcoma (KS) is the most common Acquired Immune Deficiency Syndrome (AIDS)-related malignancy globally and is of particular significance in sub-Saharan Africa where, due to the Human Immunodeficiency Virus (HIV) epidemic, KS is the cause of significant morbidity and mortality. The …
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The Role of ORF59 and PAN ENE in Viral Replication of KSHV
Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus and the etiological agent for a number of oncogenic diseases including Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL). Similarly to other herpesviruses, KSHV can …
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
… the human pathogens Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). MHV68, EBV, and KSHV are lymphotropic and are associated with a variety of lymphadenopathies, carcinomas, and lymphomas. B cells are the main latent reservoir of gammaherpesviruses. A central question …
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The biological effects of HIV-1 Nef on the development of B-cell Lymphoma
… of established oncogenic viruses such as the Kaposi's Sarcoma-associated Herpes Virus (KSHV), or with Epstein-Barr Virus (EBV). To date, convincing evidence assign oncogenic activity to the HIV viral proteins Trans-activator of Transcription (Tat) and p17 in the progression of B-cell …
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Systematic Kaposi-Sarcoma Herpesvirus (KSHV) genome analysis from a South African HIV- and KSHV-positive patient cohort
Kaposi sarcoma herpesvirus (KSHV) is an oncogenic virus and the etiological agent of Kaposi's sarcoma, the most common AIDS-associated cancer. KSHV infection occurs primarily in Sub-Saharan Africa (SSA) where it is also associated with other pathologies such as Multicentric Castleman's Disease, …
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A study to understand the experiences of adolescents and young adults living with cancer in a northern cape public health setting
… Syndrome-related malignancies such as Kaposi's sarcoma, cervical cancer, and non-Hodgkin's lymphoma. Six key themes emerged that provided insight into the challenges experienced by AYAs with cancer. These challenges were interrelated on a physical, psychosocial, spiritual and healthcare …