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Showing 1 to 2 of 2 for “"Kallikrein Inhibitor"”.
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
Plasma kallikrein plays an important role in the pathogenesis of inflammation and thrombosis. Kallikrein cleaves high molecular weight kininogen (HK) to liberate the potent pro-inflammatory peptide bradykinin (BK). BK upon activation of its constitutive B2 receptors on endothelial cells leads to an …
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Organometallic Palladium Reagents for Polypeptide Bioconjugation and Macrocyclization
… linked bicyclic variant of a human plasma kallikrein inhibitor. A nearly 5000-fold loss in inhibitory activity demonstrates the potential difference in bioactivity accessed by this chemical change. In addition to potential application as a bicyclic linker, peptide cross-linking is achieved …