Global ETD Search
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Showing 1 to 2 of 2 for “"Kalirin"”.
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Kalirin : novel role in osteocyte function
… with other bone cells are still unknown. Kalirin is a novel multi-domain GTP exchange factor (GEF) protein that activates the RhoGTPases. Recently, we found that 14 week old female Kalirin knockout (Kal-KO) mice exhibit a 45% decrease in trabecular bone density and have significantly lower …
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Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
… the model organism Caenorhabditis elegans, the Kalirin and Trio ortholog UNC-73 contains two RhoGEF domains that specifically activate either Rac or Rho GTPases, respectively. The RhoGEF1 domain and the Rac pathway are required for axon guidance in neuronal development, while the RhoGEF2 domain …