Global ETD Search
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Showing 1 to 16 of 16 for “"Kainic Acid"”.
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Role of Endogenous Prostaglandins on Kainic Acid Induced Seizure Activity
… and celecoxib is known to aggravate the kainic acid(KA)-induced seizure activity. However it is not known whether the pro-conversant effect of NSAID was due to the change of endogenous prostaglandins(PGs) and if so, what types are involved. This study was done to determine the effect of …
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The induction of long-term potentiation attenuates kainic acid-induced excitotoxicity
… in the anaesthetized rat. Furthermore, using the kainic acid (KA) model of neurotoxicity, this research has explored the opposing roles that activity-dependent synaptic plasticity, through different NMDAR subtypes, can play in determining neuronal outcome in an excitotoxic environment. In these …
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Asymmetric Allylation of Aldehydes Catalyzed by Formamide Organocatalysts. Studies Towards The Synthesis of L- Domoic Acid Side Chain
… of aldehydes. Classically metal-based Lewis acids are frequently used to catalyze this process. These Lewis acids are inherently sensitive to air and moisture and thus require strictly anhydrous reaction conditions. Recent developments in the field of catalysis have found chiral organic Lewis …
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ΙΔΙΟΤΗΤΕΣ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ L-ΑΣΠΑΡΤΙΚΟΥ ΚΑΙ ΚΑΙΝΙΚΟΥ ΟΞΕΟΣ ΕΓΚΕΦΑΛΟΥ ΠΤΗΝΩΝ. "ΣΥΜΒΟΛΗ ΣΤΗΝ ΑΠΟΜΟΝΩΣΗ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟ ΤΩΝ ΘΕΣΕΩΝ ΔΕΣΜΕΥΣΗΣ L-ΓΛΟΥΤΑΜΙΚΟΥ ΟΞΕΟΣ"
… A KD VALUE OF 176 NM AND 204 RESPECTIVELY. FOR KAINIC ACID TWO BINDING COMPONENTS WERE FOUND IN THE HEMISPHERES, OPTIC LOBES AND BRAIN STEM, ONE WITH HIGH AFFINITY AND A KD VALUE OF 12.5 NM AND ONE WITH LOW AFFINITY AND A KD VALUE OF 260 NM. IN CEREBELLUM ONLY ONE BINDING SITE WAS DETECTED FOR …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΚΕΤΑΜΙΝΗΣ ΣΤΟ ΜΕΛΑΙΝΟΡΑΒΔΩΤΟ ΝΤΟΠΑΜΙΝΕΡΓΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΕΓΚΕΦΑΛΟΥ
… LESIONED BY STEREOTAXIC INJECTION OF KAINIC ACID. AFTER OPERATION, THE RATS SHOWED PORTURAL ASYMMETRY, AS WELL AS IPSIVERSIVE TURNING ACTIVITY WHICH LASTED FOR ABOUT 7 DAYS. AFTER THE 20TH POSTOPERATIVEDAY THE RATS WERE INJECTED I.P. EVERY TWO DAYS ONE OF THE FOLLOWING DRUGS THAT …
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Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
… the glutamate receptor agonist, kainic acid (KA), or the GABAA receptor antagonist, pentylenetetrazole (PTZ). Paradoxically, after repeated repeated/chronic administration of the same chemoconvulsants, SLC7A11sut/sut mice exhibit signs of hypo-excitability, a response polar …
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… (CNS). Glutamate, a major excitatory amino acid in the CNS, works through four different classes of receptors; three that are heterogeneous, ionotropic excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). (RS)-2-amino-3-(3-hydroxy-5-methylisoxazole-4-yl) …
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… (CNS). Glutamate, a major excitatory amino acid in the CNS, works through four different classes of receptors; three that are heterogeneous, ionotropic excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). (RS)-2-amino-3-(3-hydroxy-5-methylisoxazole-4-yl) …
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Novel roles of striatal enriched protein phosphatase (STEP) in neuronal intrinsic properties and homeostatic synaptic plasticity
… α-amino-hydroxy-5-methyl-4-isoxazolepropinoic acid receptors (AMPARs) via dephosphorylating Tyr1472 of GluN2B subunit in NMDAR and 3 Tyr (Tyr869, Tyr873, and Tyr876) of GluA2 subunit in AMPAR. Despite extensive studies on the role of STEP61 in activity-dependent synaptic plasticity, including …
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Μελέτη των θέσεων δέσμευσης του L-γλουταμικού οξέος σε φυσιολογική και ατροφική ανθρώπινη παρεγκεφαλίδα: Συμβολή στη μελέτη της ελαιογεφυρο-παρεγκεφαλιδικής ατροφίας
… and -independent conditions for L-glutamic acid with Kd values in the order of 150Χ10⁻⁹Μ. Hill plots of these data were linear with Hill coeficient equal to 1.0. Chloride ions provoked a significant increase of L-glutamate binding, with ratio of Cl⁻-dependent/-independent binding sites about …
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Disrupted female reproductive cyclicity and gonadotropin-releasing hormone neuron dysfunction in a mouse model of temporal lobe epilepsy
… disorders are unknown. In the intrahippocampal kainic acid (IHKA) mouse model of TLE, we observed that more than 60% percent of KA-injected mice showed disrupted estrous cycles, typically characterized by increased estrous cycle length and increased time spent in diestrus estrus by 42 days …
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Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… (TLE) and maternal immune activation (MIA). The kainic acid (KA) model of temporal lobe epilepsy (TLE) was used to induce Ammon’s-horn sclerosis (AHS) and to investigate behavioural and cytoarchitectural changes that occur in the amygdala related to Neuropeptide Y1 receptor expression. Results …
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Blood plasma-mediated effects on regenerative features of a novel adult human cardiac stem cell population
… significant neuroprotective effects against kainic acid (KA)-mediated neuronal cell death compared to untreated hippocampal slice cultures. In summary, the here presented results show the identification of a novel hCSC population and its developmental relation to the neural crest as well as …
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The roles of indoeamine-2,3-dioxygenase 1 and 2 during TMEV- and kainate-induced ictogenesis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… pha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, which our lab has identified. AMPA receptors (AMPARs) are the most commonly found receptors in the mammalian nervous system, mediating fast excitatory synaptic transmission. Their distribution and activity are regulated by …