Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Kainate receptor"”.
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Cellular mechanisms that modulate kainate receptor trafficking and assembly
Kainate receptors (KARs) in the mammalian brain play a variety of physiological roles that require selective assembly, intracellular trafficking, and synaptic targeting. Cytoplasmic and non-cytoplasmic determinants that modulate KAR expression at the plasma membrane have been recently …
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The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration
<p>Though the GluK4 kainate receptor subunit shows limited homology and a restricted expression pattern relative to other kainate receptor subunits, its ablation results in distinct behavioral and molecular phenotypes. To study the function of GluK4, I generated a global GluK4 knockout mouse line …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
… production. In the CNS, signaling through the kainate receptor (KAR) by glutamate causes an increase in ADAM10 expression. Human B cells were found to express a GluK2 containing kainate receptor and its activation increased ADAM10 expression which is in agreement with KAR activation in the CNS. …
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Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology
… of the nature and effects of glutamate receptors activation has major implications in migraine pathophysiology and treatment. Here the role of kainate receptors, a member of the ionotropic glutamate receptors subfamily, was investigated in relaying sensory information upon activation of …
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A structure-function analysis of the marine toxin neodysiherbaine and its synthetic analogs on kainate receptors
Kainate receptor antagonists show efficacy in multiple animal models of neuropathologies, including pain and epilepsy. These receptors are selectively targeted by a number of natural and synthetic ligands. The goals of this project were to identify compounds with unique specificity for kainate …
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The Extracellular Domains of the AMPA, Kainate, and Orphan Delta Receptor Regulate Channel Gating in Distinct Ways
<p>The ionotropic glutamate receptors are ligand-gated cationic channels essential for neuroplasticity and neurological functions such as learning, memory, behavior, cognition, and motor coordination. Mutations in these channels are linked to various disorders including autism, ataxia, and …
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Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
<p>Ionotropic glutamate receptors (iGluRs) found in mammalian brain are primarily known to mediate excitatory synaptic transmission crucial for learning and memory formation. The family of iGluRs consists of AMPA receptors, NMDA receptors and kainate receptors with each member having distinct …
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Hippocampal output to neocortex: Examination of the electrophysiological and plastic properties of CA1 projections to the perirhinal cortex
… and that LTP-induction may require AMPA/kainate receptor activation but not NMDA receptor activation; indicating that glutamatergic signalling underlies synaptic plasticity in this projection. We also determine the role of the CA1 to perirhinal cortex projection in a model of …
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Cellular Effects of Cerebral Ischaemia In Vitro’. Cerebroprotective Actions of GABAmimetic agents
… ischaemic glutamate efflux. NMDA and AMPA/kainate receptor antagonists also inhibited glutamate efflux, fhc group II metabotropic glutamate receptor agonist DCG-IV and the endogenous nociceptin receptor agonist nociceptin inhibited glutamate efflux whilst the group 1 mGluR antagonists MI’EP …
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
… processes where they contact cone and rod photoreceptors. We further identified some known SAP102 binding partners, kainate receptor GluR6/7 and inward rectifier potassium channel Kir2.1, closely associated with SAP102 in the processes of invaginating HCs. In contrast, in the mouse retina we …
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Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels
… amiloride, apamin, 4-aminopyridine, and AMPA/kainate receptor inhibitor cyanquixaline significantly decreased invasion in U87-MG and U251-MG, effects that were additively enhanced upon co-treatment with AqB013. Interestingly, when solid tumour spheroids of U87-MG and U251-MG were treated with …
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Visualizing the dynamics of ionotropic glutamate receptors using atomic force microscopy
… different subclasses of ionotropic glutamate receptors (iGluRs): AMPA, kainate and NMDA receptors, and triggers a cation influx that generates synaptic currents crucial to brain function. Significantly, iGluRs are implicated in various neurological disorders, such as depression, schizophrenia, …
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Investigations of The Structure-Function Relationship In Kainate Receptors Using FöRster Resonance Energy Transfer
<p>Kainate receptors belong to the family of ion channels known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory synaptic transmission, modulate the release of presynaptic glutamate, and facilitate dendrite formation. Kainate receptors are …