Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"KU70/80"”.
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Investigations into Why Human (but not mouse) KU70/80 is Essential Reveal a Role for Human KU70/80 in Ribosome Biogenesis
<p>The requirement of Ku70/80 for ribosome biogenesis in higher primates explains otherwise perplexing essential nature of this double-strand break (DSB) repair factor. We have ruled out telomere protection or DSB repair as the essential function ofKu70/80. Instead, unbiased genome-wide analyses …
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Investigating the regulation of DNA non-homologous end-joining through Ku70/80 interacting factors
… factors of the core NHEJ protein heterodimer, Ku70/80 (Ku). This thesis consists of three main research projects. The first, explores the potential role of the CUL4 substrate adaptor, WDR76, in the removal of Ku from sites of DNA damage. Data presented here highlight a role of WDR76 in the DNA …
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Shedding Light on the Biological Effects of Ionising Radiation on DNA Using Advanced Optical Microscopy
… resulted in increased foci persistence. Although Ku70/Ku80 are known as major effectors in DSB repair and genome integrity, their interaction in relation to DSB repair has not been detected in living cells. Using GFP technology and advanced imaging, Ku70-80 interaction was shown for the first time …
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DNA repair and sister chromatid exchange
… protein kinase (DNA-PKcs), both the Ku70/80 heterodimer and the catalytic subunit (DNA-PKcs), and Artemis. ERCC1 is a representative member of the final DNA repair pathway examined, nucleotide excision repair (NER). Lastly, I determined if/how DNA repair status can influence the …
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Gene and Protein Expression in Human Gliomas
… of the potential tumour associated antigen Ku70/80. We show that the extracellular localisation of this protein complex is specific for tumour cells, and that it can be used as a portal for tumour specific delivery of toxin conjugated antibodies. Finally, using antibody microarrays we …