Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"KSR1"”.
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The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
… 1 (CRL4-DCAF1) and Kinase suppressor of RAS 1 (KSR1) have been shown to be upregulated in schwannoma to drive tumour growth. KSR1 has also been shown to interact with components of the CRL4-DCAF1 complex. We investigated the expression, interaction and therapeutic potential of targeting these …
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Preconditioned iterative methods on virtual shared memory machines
The Kendall Square Research Machine 1 (KSR1) is a virtual shared memory (VSM) machine. Memory on the KSR1 consists primarily of shared, physically distributed caches. Effective memory utilization of the KSR1 is studied within this thesis. Special emphasis is laid upon how best to optimize iterative …
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Mechanistic Basis of Signal Amplitude Modulation by the Ras Effector IMP
… by directly limiting the assembly of functional KSR1-dependent RAF/MEK complexes. Here, we examine the mechanistic basis of signal amplitude modulation by the Ras effector IMP. We show that the capacity of IMP to inhibit signal propagation through RAF to MEK is a consequence of disrupting …
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The Role of the Mitogen Activated Protein Kinase Pathway in Cisplatin and Noise-Induced Hearing Loss
… knocking down the MAPK pathway by utilizing KSR1 KO mice (scaffolding protein in the MAPK pathway) demonstrated that KO mice were resistant to both cisplatin and noise-induced hearing loss. Pharmacological inhibition of all three kinases in the pathway also protected mice from both cisplatin …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… by ERK-propelled feedback signaling within a KSR1 scaffold. PP2 and dasatinib had different effects on Lyn activity suggesting that Lyn acts as an adaptor/scaffold independent of its kinase function. These results provide valuable insight as to how ATRA-regulated molecules including CD38, …
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Uncovering the Complexity of RAS Signaling Networks
… appears to be through inactivation of the KSR1 adaptor/scaffold protein, demonstrating that in addition to promoting signal transmission, scaffold proteins can function to restrict signal propagation. Ras can inactivate IMP through induction of IMP auto-ubiquitination, facilitating …
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The Regulation of Cellular Localization of Both Active and Inactive ERK1/2
… proteins, such as kinase suppressor of Ras 1 (KSR1) and phosphoprotein enriched in astrocytes of 15 kDa (PEA15), a protein overexpressed in type II diabetes. In this study I mutated two serine residues on PEA15. Phosphorylation of these residues is known to affect ERK1/2 binding and …