Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"KSHV"”.
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Systematic Kaposi-Sarcoma Herpesvirus (KSHV) genome analysis from a South African HIV- and KSHV-positive patient cohort
Kaposi sarcoma herpesvirus (KSHV) is an oncogenic virus and the etiological agent of Kaposi's sarcoma, the most common AIDS-associated cancer. KSHV infection occurs primarily in Sub-Saharan Africa (SSA) where it is also associated with other pathologies such as Multicentric Castleman's Disease, …
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KSHV Susceptibility and Transmission Within Tonsillar Specimens
… regarding the early stages of development for KSHV lymphoproliferative disorders, hindering our ability to develop prophylactic measures or effective treatments. This dissertation will focus on the host and viral factors influencing the magnitude and dynamics of KSHV infection in the human …
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Viral Factors Influencing Early Infection Events During Ex-Vivo KSHV Infection
… this virus. Kaposi Sarcoma Herpes Virus (KSHV), also known as Human Herpesvirus 8 (HHV8), is the etiological agent of Kaposi Sarcoma (KS) and other lymphoproliferative cancers, such as Multicentric Castleman’s Disease (MCD), Primary Effusion Lymphoma (PEL), and a newly discovered rare …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
Kaposi's Sarcoma-Associated Herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is a tumorigenic herpesvirus tightly linked with various human malignancies including Kaposi's Sarcoma, Primary Effusion Lymphomas (PELs), and Multicentric Castleman's Disease. Immunocompetent individuals infected with …
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The Role of ORF59 and PAN ENE in Viral Replication of KSHV
Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus and the etiological agent for a number of oncogenic diseases including Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL). Similarly to other herpesviruses, KSHV can …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
<p>Kaposi sarcoma-associated herpesvirus (KSHV) is the etiologic agent of kaposi sarcoma. It is also associated with the B cell lymphoproliferative disorders, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research …
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Influence of Human and Viral IL-6 on KSHV Infection in Human Tonsil Lymphocytes
… Kaposi sarcoma-associated herpesvirus (KSHV) causes Multicentric Castleman Disease, Primary Effusion Lymphoma, and the newly-identified inflammatory syndrome designated KICS. Despite proven connections to lymphoproliferative disorders, little is known about how KSHV invades the human …
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Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… sarcoma-associated herpesvirus, also known as KSHV or HHV-8, is an emerging pathogen and the causative agent of multiple cancers in immunocompromised patients. KSHV is known to cause four types of malignancies: endothelial-based Kaposi Sarcoma (KS), two rare B cell- based lymphomas; Primary …
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Molecular genetics and functions of Kaposi's sarcoma-associated herpesvirus glycoproteins in viral entry and virus-induced cell fusion
Kaposi’s sarcoma-associated herpesvirus (KSHV) is considered the etiologic agent of Kaposi’s sarcoma and several lymphoproliferative disorders. Recently, the full-length KSHV genome has been cloned into a bacterial artificial chromosome (BAC) and successfully recovered in 293 cells. The herpesviral …
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Relationship of HHV8 serum levels and clinical features of Kaposi's sarcoma among patients in South Africa
… by Kaposi's Sarcomaassociated Herpesvirus (KSHV). The level of HIV immune suppression and extent of KSHV DNA determine the development of Kaposi's sarcoma. Common manifestations of Kaposi's sarcoma include skin and mucosa} involvement. lympboedema. and viscera] disease. Objectives. The …
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The impact of EPHA2 polymorphism on KSHV infectivity and KS prevalence among HIV/AIDS patients in South Africa
… Kaposi's Sarcoma-associated herpes virus (KSHV) is the etiological agent of KS. Although KSHV seroprevalence in sub-Saharan Africa is high, not all AIDS patients develop KS, suggesting that host genetic factors contribute to susceptibility. The infection mechanism of KSHV in endothelial …
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The reactivation of Kaposi's Sarcoma-associated Herpesvirus (KSHV) by SARS-CoV-2 in non-hospitalised HIV-infected patients
… and Kaposi's Sarcoma Associated Herpes Virus (KSHV). SARS-CoV-2 co-infection with herpesviruses has been suggested to have an impact on acute and/or long-term disease progression by triggering their reactivation from latency. We have previously reported that lytic KSHV infection (assessed by …
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Characterisation of Kaposi's sarcoma-associated herpesvirus (KSHV)-driven pathology and disease outcome in HIV infected South African patients
Kaposi's sarcoma-associated herpesvirus (KSHV), a gamma-herpesvirus with a particularly high seroprevalence in Sub-Saharan Africa (SSA), is the etiological agent of the endothelial tumour Kaposi's sarcoma (KS), the most common acquired immunodeficiency syndrome (AIDS)-related malignancy worldwide …
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The PNUTS-PP1 Complex Acts as an Intrinsic Barrier to Kaposi's Sarcoma Associated Herpesvirus Gene Expression and Replication
… The Kaposi's sarcoma-associated herpesvirus (KSHV) co-opts pol II to express its genes, but little is known about its regulation of pol II elongation. I identified PNUTS as a suppressor of a KSHV reporter gene in a genome-wide CRISPR screen. PNUTS depletion enhances global KSHV gene expression …
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Statistical analysis of protein interaction network topology
… the protein-protein interaction network of the KSHV herpesvirus, which is the first viral system available, and compare it to a prototypical cellular system. On the local level, we investigated the relationship between interaction and sequence evolution, functional class, phylogenetic class, and …
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
… and Kaposi's sarcoma-associated herpesvirus (KSHV). MHV68, EBV, and KSHV are lymphotropic and are associated with a variety of lymphadenopathies, carcinomas, and lymphomas. B cells are the main latent reservoir of gammaherpesviruses. A central question is how B cell signaling regulates viral …
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Cloning and expression of a functionally active truncated N-glycosylated KSHV complement regulatory protein and immunohistochemical studies with the anti-KCP peptide antibody
Kaposi sarcoma herpes virus (KSHV) is a typical DNA virus that is associated with a number of proliferative diseases including Kaposi's sarcoma. The KSHV open reading frame (ORF) 4 encodes a complement regulatory protein (Kaposi complement-binding protein, KCP) that binds complement proteins and …
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Characterization of the Interactions Between Kaposi’s Sarcoma-Associated Herpesvirus ORF57 and Its RNA Partners
Kaposi's sarcoma-associated herpesvirus (KSHV; HHV-8) is a human gammaherpesvirus and the etiological agent of Kaposi's sarcoma (KS), the most common AIDS-associated malignancy. Like all herpesviruses, KSHV has evolved mechanisms to modulate both host and viral gene expression. The essential and …
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Translational initiation controls localization and regulatory function of the gamma-herpesviral protein kaposin
Kaposi's Sarcoma Associated Herpesvirus (KSHV) or Human Herpesvirus-8 (HHV-8) is the most recently identified human gamma-2 herpesvirus and has been implicated in Kaposi's Sarcoma (KS) and primary effusion lymphoma (PEL). At the right end of the genome KSHV encodes the complex kaposin locus, which …
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