Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"KRAS inhibitor"”.
-
Light-Mediated Dual Catalysis for C–N Bond Formation
… evidenced by the recent FDA approval of KRAS inhibitor sotorasib.4 This work describes the design of a mechanistically distinct photocatalytic activation mode that enabled the selective cross-coupling of aryl iodides and 6-substituted 2-pyridones. Mechanistic investigations revealed the …
-
Investigating the requirement of KRAS for the maintenance of pancreatic cancer
… have identified mutations in the proto-oncogene KRAS as a hallmark of PDAC, making KRAS an attractive therapeutic target. While the driver role of oncogenic KRAS for PDAC initiation has been well established, the degree of KRAS oncogene addiction in established PDAC tumors remains unclear. To …
-
Structure Based Drug Design of High Affinity Kras Inhibitors
… for more than 30 years an FDA approved direct inhibitor has not yet been developed. There are three isoforms of RAS in cells; HRAS, NRAS and KRAS. We focused on KRAS since it is the most frequently mutated isoform in cancer. To identify novel non-covalent small molecules that bind to mutant …