Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"KRAB-ZFP"”.
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… box-containing zinc finger proteins (Krab-ZFPs). Silencing is initiated by the recruitment of TRIM28 to a target locus by members of the Krab-ZFP. Subsequently, TRIM28 functions as a scaffold protein to recruit chromatin modifying effectors featuring SETDB1 (SET domain bifurcated …
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Unlocking Compacted Heterochromatin Through Modulation Of Associated Proteins
… In an additional study, I investigated how KRAB domain-containing zinc finger proteins (KRAB-ZFPs) might silence hepatic genes in alternate lineages. I identified six putative liver lineage antagonistic KRAB-ZFPs. A mostly unstudied primate-specific KRAB-ZFP known as ZNF695 became the top …
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A TRIM28 centric strategy to efficiently uncover the contribution of KZFPs to the evolution of gene regulatory networks
The family of KRAB zinc-finger proteins (KZFPs) is the largest group of DNA-binding factors in tetrapods and is rapidly evolving, with >350 protein-coding members in humans. While the individual roles of most human KZFPs is poorly characterized, it is known that their primary role is to …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
… similar pattern to Mta3, mice deficient in Roma (Zfp157), a newly characterised Krüppel-associated box zinc finger protein, exhibited hyperproliferation in mammary epithelial cells (MECs) during early pregnancy. Roma/Zfp157 (Regulator Of Mammary Alveologenesis), has been shown by the Watson …