Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"KRAB Zinc Finger Proteins"”.
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Primate-specific KRAB zinc finger proteins and their targets rewire regulatory networks related to inflammation and pancreas development
… subfamily of DNA binding factors in human, KRAB Zinc Finger proteins (KZFPs), leads to the epigenetic silencing of their bound loci and have been recently shown to mainly target repetitive regions of the genome, mostly TEs. Interestingly most TEs targeted by KZFPs have lost their ability to …
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The KRAB Zinc Finger Protein ZKSCAN3 binds to a SINE-embedded regulatory sequence to repress enhancer activity
KRAB Zinc Finger Proteins (KZFPs) are the largest family of transcription factors in mammals and are generally associated with the binding and repression of transposable elements. KZFPs use their KRAB domain to recruit the cofactor KAP1, which acts as a scaffold for the induction of …
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A TRIM28 centric strategy to efficiently uncover the contribution of KZFPs to the evolution of gene regulatory networks
The family of KRAB zinc-finger proteins (KZFPs) is the largest group of DNA-binding factors in tetrapods and is rapidly evolving, with >350 protein-coding members in humans. While the individual roles of most human KZFPs is poorly characterized, it is known that their primary role is to …
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Identification and characterisation of KZFPs directly regulated by p53
… our genome across evolutionary history. KRAB zinc finger proteins (KZFPs) are the largest group of DNA binding factors in the human genome and mostly target TEs, controlling chromatin accessibility by effecting epigenetic changes at their binding sites which result in a localized …
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Using a novel large-scale epigenetic analysis method to uncover the cis-regulatory potential of individual transposable elements
… potential. One such mechanism is orchestrated by KRAB zinc finger proteins (KZFPs). These form the largest family of DNA binding factors in tetrapods, with more than 350 protein-coding members in humans. While little is known about their individual function, they have a recognised general role in …