Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"KPC mouse model"”.
-
PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN
… recapitulated in a Kras G12D p53 H172R Pdx1-Cre (KPC) mouse model. We examined the efficacy of PTEN-Long treatment alone or in combination with gemcitabine in the KPC model. To our surprise PTEN-Long preformed equivalently to gemcitabine as a monotherapy, and the animals had a significantly …
-
Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… Results: Using syngeneic, *in vivo* murine models of PDAC with differential immune infiltration and response to IOT and the KPC mouse model, CD39 and CD73 were shown to be highly expressed on tumour-infiltrating immune cells. The distribution of extracellular adenosine appeared heterogeneous …
-
Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… around its wider impact on stromal remodeling and immunological activation. This study investigates the immunomodulatory effects of RFA combined with neoadjuvant chemotherapy in clinical samples and in combination with immune checkpoint blockade using a syngeneic pancreatic cancer …