Global ETD Search
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Showing 1 to 2 of 2 for “"KOR agonists"”.
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
… while activation of the kappa opioid receptor (KOR) has the opposite effect. Activation of the KOR causes a decrease in dopamine levels in reward-related regions of the brain, and can block the rewarding effects of various drugs of abuse, making it a potential drug target for addictive diseases. …
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Molecular Regulation of Opioid Receptor Signaling
… behavioral effects of kappa opioid receptors (KOR) are mediated through different signaling cascades. KOR activation of G protein-dependent signaling results in analgesia, whereas the dysphoric effects are mediated by a different pathway involving G protein-coupled receptor kinase (GRK) and …