Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"KO rats"”.
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Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome
… twenty years, mainly focusing on the Fmr1 knockout (KO) mouse, have uncovered several cellular and behavioural phenotypes associated with the loss of FMRP. Seminal work using the Fmr1 KO mouse found that metabotropic glutamate receptor mediated long-term depression (mGluR-LTD) in the …
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Modelling fragile X syndrome in rats: new directions in translational research
… the validity of a new rat model for FXS (Fmr1 KO rat). I showed that Fmr1 KO rats exhibit normal spatial navigation memory, social interactions and anxiety levels. On the contrary, when subjects were tested in a battery of spontaneous exploration tasks: object recognition (OR), object-context …
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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
… NADPH oxidase-dependent oxyradical generation. Rats subjected to glycerol-induced rhabdomyolysis also exhibited ROS-dependent ET-1 production. Vasoactive ET-1 is generated by ET converting enzyme 1 (ECE-1)-induced proteolytic processing of inactive big ET to biologically active peptides. The …