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Showing 1 to 5 of 5 for “"KMT2A"”.

  1. A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels

    Issa, Ghayas, <p>0000-0002-4339-8683</p>2024

    … of the lysine methyltransferase 2 A gene (<em>KMT2Ar</em>) have an adverse prognosis with more than 80 possible fusion partner genes (FPG) identified. With the advent of effective targeted therapies for <em>KMT2Ar</em> leukemia such as menin inhibitors, there is an unmet need for sensitive …

    uthsc Repository record

  2. The role of non-genetic variability in Acute Myeloid Leukaemia

    Gupta, ShikhaUniversity of Cambridge2021

    … model for Kat2a our lab showed that it sustains KMT2A/MLLT3 AML stem cells. Kat2a is a classical regulator of transcriptional variability, its loss leading to cell-to-cell heterogeneity in transcription levels, including from genes involved in ribosomal biogenesis and translation (Domingues et …

    cambridge Repository record

  3. The impact of hypoxia on out-of-field signalling responses following exposure to modulated irradiation

    Thompson, HannahQueen's University Belfast2020

    … alterations in KCNMA1, KDM1A, PNISR, RBM6, and KMT2A out-of-field could not be replicated by RT-qPCR on this occasion. <br/>Conclusion: Overall, the data presented here provides evidence for out-of-field cells relying on intercellular signalling generated by irradiated cells under hypoxic …

    qu-belfast Repository record

  4. From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics

    Kennedy, AlisonUniversity of Cambridge2023

    … Rearrangements involving the *MLL1* gene (*Kmt2a*) produce powerful oncogenic proteins occurring predominantly in paediatric and infant acute myeloid and lymphoid leukaemias. Despite having more than 80 fusion partners, MLL-AF9, MLL-AF4 and MLL-ENL make up more than 60% of cases involving …

    cambridge Repository record

  5. The Mechanisms of HOXA9-mediated Acute Myeloid Leukaemia Maintenance

    Beinortas, TumasUniversity of Cambridge2024

    … and is an established therapeutic target: KMT2A-fusion, NUP98-fusion and mutated NPM1 driven AMLs not only highly express HOXA9 but also depend on HOXA9’s expression for survival, whereby downregulation of HOXA9 is associated with differentiation and apoptosis. Despite its established …

    cambridge Repository record