Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 39 for “"KLF4"”.
-
KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… the transcription factor Krüppel-like factor 4 (KLF4) in ECs in vivo. KLF4 promotes an endogenous production of bone morphogenetic protein 6 (BMP6) in ECs that, in turn, activates the transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signalling pathway. KLF4 …
-
Molecular mechanisms of Kruppel-like Factor 4
… our lab demonstrated that Kruppel-like factor 4 (KLF4) interacts with beta-catenin in vivo, repressing Wnt signaling and inhibiting tumor growth. KLF4 is an anti-proliferative transcription factor expressed in differentiated epithelial cells in the intestine. Previous studies clearly establish …
-
Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
The zinc finger protein and transcription factor, KLF4, plays a vital role in the regulation of lineage differentiation during development, as well as the maintenance of epithelial homeostasis in the intestine. KLF4 is predominantly expressed in the epithelial cells that are fully differentiated in …
-
TCF4-mediated Transcriptional Regulation of Krüppel-like Factor 4 Gene
Krüppel-like factor 4 (KLF4)은 체세포에서 reprogramming 하는 역할에 필수적이다. 또한 KLF4은 다양한 조직에서 발연하고 세포증식, terminal differentiation, 세포사멸과 같은 많은 생리적 과정에서 중요한 역할을 수행한다. 그 기능으로는 일반적 항상성, 세포 분화, 그리고 암 형성에 밀접하게 관여한다. 이런 조직 특이성에 대한 전사적 결정을 드러내도록 노력하기 위해 우리는 transcription factor 4 (TCF4) 단백질이 binding 하는 것으로 알려진 두 개의 …
-
Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
… co-binding of Kruppel-like transcription factors Klf4 and Zfp281. In contrast to other factors that interact in a positive feedback network stabilizing mESC cell-type identity, Klf4 and Zfp281 drive opposing transcriptional and chromatin programs. Abrogation of factor binding to DATEs dampens …
-
Defining Epithelial Cell Fate Dynamics of the Oesophagus during Postnatal Development and Homeostasis
… emergence of a new basal population expressing KLF4, which is known to mark keratinocyte differentiation. Next, I questioned the relevance of the KLF4+ basal population by analysing proliferative capacity and the associated keratin profile. The results indicated KLF4 as a marker of commitment …
-
Mechanism of Rare Variant In Acta2, P.Arg149Cys, Driving Diverse Vascular Disease
… is dependent on Kruppel-like factor 4 (Klf4).<strong> </strong>We previously demonstrated that SMCs treated with free cholesterol complexed to methyl-β-cyclodextrin (MBD-Chol) <em>in vitro</em> induces endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR) …
-
Transcriptional Regulation Of Adipocyte Function
… not been defined invivo. In this thesis, firstly KLF4 was discovered to be an essential early regulator of adipogenesis. KLF4 together with Krox20 cooperatively transactivates C/EBPβ, suggesting that KLF4 and Krox20 are part of an immediate early transcriptional network. This network is …
-
USING A NOVEL CELL- PENETRATING PEPTIDE TECHNOLOGY TO INDUCE PLURIPOTENCY
… required to induce pluripotency: Oct4, Sox2, Klf4, and c-Myc (OSKM). Since then, pluripotency has been induced with OSKM most effectively by transfection or transduction. However, both are difficult to control and can have undesirable off-target effects, e.g. random mutations in the genome. A …
-
Reprogramming cellular fate using defined factors
… transcription factors, Oct4, Sox2, c-Myc and Klf4 can induce a pluripotent state in somatic cells, without the need for embryo destruction. The work presented here aims to characterize reprogramming using defined factors and provide insight into the mechanisms governing this process. It also …
-
Hypoxia signalling regulates human lung epithelial cell fates
… factors. I further examined functions of KLF4 and KLF5 in lung epithelial progenitors with CRISPRi. KLF4 and KLF5 facilitated differentiation of progenitors to basal and secretory cells in both hypoxia-induced and chemical-induced airway differentiation processes. These results suggest …
-
Single-cell analyses of cellular reprogramming and embryonic stem cells
… transcription factors: Oct4, Sox2, c-Myc, and Klf4. During cellular reprogramming, only a small fraction of cells become iPSCs. Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identification of reprogramming events. Using …
-
In Vitro Models of Cellular Dedifferentiation for Regenerative Medicine
… the transcription factors Oct4, Sox2, cMyc, and Klf4 to create a line of naive-like porcine induced pluripotent stem cells (iPSCs). This reprogramming vector was verified first in murine cells, the system in which it was developed. Successful production of both murine and porcine iPSC lines was …
-
Συσχέτιση γονιδιωματικών βιοδεικτών σε γονίδια της οικογένειας KLF με τα επίπεδα της εμβρυικής αιμοσφαιρίνης στον άνθρωπο : προεκτάσεις στην εξατομίκευση της θεραπείας με υδροξυουρία ασθενών με β-τύπου αιμοσφαιρινοπάθειες
… rs11142398 και rs980112 των γονιδίων Klf3, Klf4, Klf9, Klf10 αντιστοίχως). Διερευνήθηκε τόσο η πιθανή τους συσχέτιση με τα αυξημένα επίπεδα της εμβρυικής αιμοσφαιρίνης, άρα και με την ηπιότερη κλινική εικόνα των β-θαλασσαιμικών ασθενών, όσο και η αντίστοιχη πιθανή συσχέτισή τους με την …
-
Identification of Undifferentiated Human Embryonic Stem Cell-Specific Genes
… as Pou5F1 (Oct4, Oct3/4), Sox2, Nanog, LIN28, KLF4, Myc(c-Myc) maintained a pluripotent undifferentiated state. As we know, both stem cells and cancer cells have self-renewal ability. To investigate for the mechanism that maintain the self-renewal and proliferation ability, we identified 11 …
-
MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation
… differentiation in skin, such as CEBPα, OVOL-1, KLF4, TCFAP2-γ and SIN3A, among others. I demonstrated that MYC recruits a specific set of tissue-specific transcription factors to the EDC, (e.g. KLF4 and OVOL-1) and thereby prevents binding of a different and distinct set of genomic regulators, …
-
An investigation into the regulation and expression of the tumour suppressor gene clusterin in oral, cervical and nasopharyngeal cancer
… Seven genes, DKK3, TIMP1, CADM1, AKAP12, KLF4, RNASET2 and CLU were identified to be candidate tumour suppressor genes in cervical neoplasia and subsequent validation led to an evaluation of the regulation and expression of CLU at three sites of squamous cancer: the oral cavity, cervix and …
-
Analysis of combinatorial gene regulation with thermodynamic models
… genes. This network suggests that Oct4, Sox2 and Klf4 indirectly repress lineage specific differentiation genes by activating transcriptional repressors of Ctbp2, Rest and Mtf2.
-
Transdifferentiation of fibroblasts to neural stem cells
… of transcription factors Oct4, Sox2, Klf4, and c-Myc, which reprogram a differentiated cell!s nucleus to one that is transcriptionally and epigenetically indistinguishable from an embryonic stem (ES) cell. However, it is still unclear if transcription factors can completely convert the …
-
Transcending the Cell Fate Stereotype: Cell Penetrating Peptide Technology helps Induce Pluripotency in Multiple Cell Types
… key transcription factors (TFs): Oct4, Sox2, Klf4, and c-Myc also known as OSKM. These TFs have been shown to be involved in maintaining pluripotency and inhibiting embryonic stem (ES) cell differentiation. Reprogramming fibroblasts into iPSCs is most efficiently accomplished by viral …
Page 1 of 2