Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"KLF2"”.
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Functional analysis of KLF2 and its lymphoma-derived mutants
… studies show recurrent somatic mutations in KLF2, and genes in the NOTCH2, NF-κB, BCR and TLR signalling pathways – pathways that are essential for the development and maintenance of marginal zone B cells. Of these, KLF2 mutations are the most frequent (20-42%) and are thought to lead to the …
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Analysis of Mouse EKLF/KLF2 E9.5 Double Knockout: Yolk Sac Morphology and Embryonic Erythroid Maturation
… in primitive and definitive erythropoiesis; KLF2 is implicated in the development of primitive erythroid and endothelial cells of the vasculature. Using light and electron microscopy, the yolk sacs and dorsal aortae from EKLF/KLF2 double knockout (KO) E9.5 (embryonic day 9.5) were examined to …
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The Roles of Krüppel-like Transcription Factors KLF1 and KLF2 in Mouse Embryonic and Human Fetal Erythropoiesis
… two Krüppel-like transcription factors, KLF1 and KLF2, which have known roles in the processes of primitive and definitive erythropoiesis as well as globin gene regulation. The regulation of primitive erythropoiesis by KLF1 and KLF2 is studied using the mouse as a model system because it is not …
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Identification of the ERK5 Kinase as a Key Regulator of Embryonic Stem Cell Pluripotency
… the core naïve pluripotency transcription factor KLF2. ERK5 directly phosphorylates KLF2 at tandem Thr-Pro/Ser-Pro motifs, which form consensus binding sites for the Peptidyl-Prolyl Isomerase PIN1. KLF2 phosphorylation at these sites promotes ubiquitylation and degradation. These results identify …
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Biomechanical regulation of arteriogenesis : defining critical endothelial-dependent events
… In particular, the transcription factor KLF2 was upregulated by the ACC waveform and several of its downstream targets displayed the expected modulation, including the downregulation of Connective tissue growth factor (CTGF). Moreover, delivery of endothelial conditioned medium generated …
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The Roles of Krüppel-Like Factor 1 (KLF1) in the Human Fetal Erythroid Compartment.
… KLF1 knockdown but not in cells with low KLF1. KLF2 mRNA amounts are usually increased in KLF1 knockdown. KLF1 knockdown in CD34+ cells results in reduced colony forming ability. Interestingly, the expression of certain proliferation and cell cycle genes is reduced due to KLF1 knockout in mouse …
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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis
… receptor 1 (S1PR1) and the transcription factor KLF2. In contrast, terminally differentiated KLRG1+ type 1 helper T cells (Th1) cells exhibit elevated expression of S1PR1 and KLF2, but are CD69low. These expression profiles likely explain the differential localization of these Mtb-specific cell …
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Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
… the upregulation of krüppel-like factor 2 (KLF2), endothelial nitric oxide synthase (eNOS) and thrombomodulin (TM) in VECs exposed to FSS. This work identifies a potential novel specific therapeutic target for the treatment or prevention of atherosclerosis and improves our understanding of …
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THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT
… Oxide Synthase-3) and Krüppel-Like Factor 2 (KLF2) expression relative to TCE exposure. Additionally, we assessed cardiomyocyte function by isolating chick E18 cardiomyocytes from embryos exposed to TCE in ovo. Cells were measured for rate of contraction after pulsing with extracellular Ca2+ …
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Understanding transcriptional regulation through computational analysis of single-cell transcriptomics
… Three different driver genes, namely Esrrb, Klf2 and GY118F, were shown to drive reprogramming of epiblast stem cells via different reprogramming routes. As for the leukaemia system, FLT3-ITD and IDH1-R132H mutations were shown to interact with each other and potentially predispose some cells …
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Mechanisms behind the fate of early chromosomal and transcriptional heterogeneities in the mouse embryo
… carried out at the 4-cell stage and compared. Klf2 and Tdgf1 were found to be important downstream targets of Sox21 that influence lineage segregation. Depletion of both these genes predisposed cells to the TE lineage. Co-overexpression of both these genes rescued the effect of Sox21 knockdown …
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Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
… in the transcription factor network (a lack of KLF2, ESRRB and TCF7L1) and a repurposing of the signalling cascades (a higher requirement for NODAL signalling and is its expression is dampened by TCF7L1).
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Hormones, Simulated Microgravity and Hypergravity affect Bone and other Physiological Systems in Zebrafish Larvae
… (hes5, sox10, lgals3bp, egr1, edn1, fos, fosb, klf2, gadd45ba and socs3a) whose expression was consistently affected by the transition from hyper- to normal gravity.