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Showing 1 to 8 of 8 for “"KLF1"”.
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The Roles of Krüppel-Like Factor 1 (KLF1) in the Human Fetal Erythroid Compartment.
<p>Erythroid Krüppel-like factor (EKLF or KLF1) is a transcription factor with roles in embryonic and adult erythropoiesis. KLF1 knockout mouse embryos die due to severe anemia. Dominant human mutations in KLF1 can cause hereditary persistence of fetal hemoglobin. We show that KLF1 positively …
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The Roles of Krüppel-like Transcription Factors KLF1 and KLF2 in Mouse Embryonic and Human Fetal Erythropoiesis
… role of two Krüppel-like transcription factors, KLF1 and KLF2, which have known roles in the processes of primitive and definitive erythropoiesis as well as globin gene regulation. The regulation of primitive erythropoiesis by KLF1 and KLF2 is studied using the mouse as a model system because it …
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Genetic programming of human iPSC-derived macrophages provides a tool to study the Erythroblastic Island niche in vitro
… of RBCs in vitro. The transcription factor KLF1 has been reported to play an important role in murine EI-like macrophages, and we noted the deficient expression of KLF1 in macrophages derived from iPSCs in vitro. We, therefore, hypothesised that enforced expression of KLF1 might programme …
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Determinanti genetici dell’espressione dell’emoglobina HbF
… mutations in human Kruppel-like factor 1 (KLF1) recently reported to be responsible for persistence of high levels of fetal hemoglobin (HPFH) and two new predicted polymorphisms (HBE1 rs67385638; HBG2 rs2855122) involved in the increased HbF and HbA2 levels. Methods: We selected 4 cohorts …
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Genetic basis of hereditary persistence of fetal haemoglobin
… Heterozygosity for ten novel mutations in the KLF1 gene were indentified in patients with a high HbF indicating that a single altered KLF1 allele can elevate HbF. The identification of a KLF1 mutation in an individual with a particularly mild form of sickle cell disease could provide in-vivo …
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Characterisation of two genetic loci involved in fetal haemoglobin production: BCLIIA and HBSIL-MYB intergenic region
… In addition, we analysed binding of GATA-1 and KLF1, two major erythroid-specific transcription factors. Strong GATA-1 binding at the HMIP region coinciding with strong histone acetylation and RNA polymerase II activity was seen, indicative of the presence of regulatory elements in the …
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The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression
… directly to and positively regulates both the KLF1 and BCL11A genes, which encode transcription factors critical for γ-globin gene silencing during β-type globin gene switching. Remarkably, less than 50% knockdown of Mi2β is sufficient to significantly induce γ-globin gene expression without …
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REGULATION OF Fas-MEDIATED APOPTOSIS BY THE Fas ANTI-SENSE NON-CODING RNA "Saf"
… for the erythroid-specific transcription factors KLF1 and GATA1. Chromatin immunoprecipitation (ChIP) assays confirmed binding of both factors to their target sequences and luciferase reporter constructs revealed synergistic activity evidenced by increase in luciferase expression relative to …