Global ETD Search
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Showing 1 to 12 of 12 for “"KLF"”.
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Συσχέτιση γονιδιωματικών βιοδεικτών σε γονίδια της οικογένειας KLF με τα επίπεδα της εμβρυικής αιμοσφαιρίνης στον άνθρωπο : προεκτάσεις στην εξατομίκευση της θεραπείας με υδροξυουρία ασθενών με β-τύπου αιμοσφαιρινοπάθειες
… επισήμανσης που εδράζονται σε 4 γονίδια Klf (συγκεκριμένα, οι πολυμορφισμοί rs2242189, rs2236599, rs11142398 και rs980112 των γονιδίων Klf3, Klf4, Klf9, Klf10 αντιστοίχως). Διερευνήθηκε τόσο η πιθανή τους συσχέτιση με τα αυξημένα επίπεδα της εμβρυικής αιμοσφαιρίνης, άρα και με την …
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Duality of magmatism at Kirkland Lake, Ontario, Canada.
… to as the Kirkland Lake-Larder Lake fault zone (KLF). The occurence of two distinct suites of magmatic rocks, syenitic and granitic, in and around the KLF indicates a magmatic duality. It is possible to identify three distinct magmatic domains defined by mode of emplacement, minerology and …
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Analyses of hematopoiesis and lineage commitment from ES and iPS cells
… durch ektopische Expression von Sox-2, Oct-4 und Klf-4 generiert worden waren, aufgrund ihres epigenitischen Gedächtnisses in vitro effizienter in hämatopietische Zellen differenzieren als ES-Zellen. Erstaunlicherweise war die Effizienz der Differenzierung von iPS-Zellen im Vergleich zu ES-Zellen …
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Determinanti genetici dell’espressione dell’emoglobina HbF
… mutations in human Kruppel-like factor 1 (KLF1) recently reported to be responsible for persistence of high levels of fetal hemoglobin (HPFH) and two new predicted polymorphisms (HBE1 rs67385638; HBG2 rs2855122) involved in the increased HbF and HbA2 levels. Methods: We selected 4 cohorts …
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Genome-wide identification of enhancers, transcription factors, and mechanisms that control skeletal muscle differentiation in cattle
… with binding sites for MyoD, AP-1, AP-4, KLF, TEAD, and MEF2 transcription factors. Through siRNA-mediated knockdown, AP-4 was found to be essential for differentiation of bovine satellite cells into myotubes. The objective of the third study was to identify enhancers and transcription …
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Molecular mechanisms of Kruppel-like Factor 4
… our lab demonstrated that Kruppel-like factor 4 (KLF4) interacts with beta-catenin in vivo, repressing Wnt signaling and inhibiting tumor growth. KLF4 is an anti-proliferative transcription factor expressed in differentiated epithelial cells in the intestine. Previous studies clearly establish …
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Neoblast specialization during regeneration of the planarian S. mediterranea
… tissues. Furthermore, the transcription factors klf, Pax3/7, and FoxA were required for the differentiation of cintillo-expressing sensory neurons, dopamine- beta-hydroxylase-expressing neurons, and the pharynx, respectively. The planarian nervous system is comprised of numerous different cell …
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Einfluß des Betablockers Bisoprolol auf den myokardialen Energiestoffwechsel, die linksventrikuläre Funktion, Ventrikelgeometrie, Hämodynamik und "Quality of Life" bei Patienten mit Dilatativer Kardiomyopathie
… Sowohl im Gesamtscore als auch im Subscore „KLF“, der die körperliche Leistungsfähigkeit beschreibt, schätzen die mit Bisoprolol behandelten Patienten ihren Gesundheitszustand im Verlauf deutlich besser ein als die Patienten der Placebogruppe. Die vorliegenden Ergebnisse zeigen, daß die Gabe …
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Hypoxia signalling regulates human lung epithelial cell fates
… I identified direct HIF target genes, including KLF-family transcription factors. I further examined functions of KLF4 and KLF5 in lung epithelial progenitors with CRISPRi. KLF4 and KLF5 facilitated differentiation of progenitors to basal and secretory cells in both hypoxia-induced and …
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Applying integrative computational models to study the evolution of gene regulation
… When applied to study the binding regions of KLF in embryonic stem cells, GibbsModule discovered a new functional motif. We also used ChIP followed by qPCR to demonstrate that the binding affinity of GibbsModule predicted binding sites are stronger than non-predicted motifs. Both genome …
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Hormoneller Einfluss und Effekte des HDAC-Inhibitors TSA in der T-47D- und der MCF-7-Brustkrebszelllinie
… clusterin (CLU) and the Kruppel-like factor 4 (KLF 4), both under regulation of estrogen and progesterone.RESULTS: The results of increasing the TSA dose show that a dose higher then 0.5µM/l TSA leads to an explicit inhibition of cell growth and induction of apoptosis which can be explained by a …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… miR-340-5p, miR-29c-3p), MYB (miR-105-5p), KLF-3 (miR-106b-5), and SP1 (miR-29b-3p, miR-625-5p, miR-324-5p, miR-125a-5p, miR-99b-5p, miR-374b-5p, miR-145-5p). The present thesis started by highlighting the scarcity of studies investigating variable responses to pain in SCD patients and then …