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Showing 1 to 8 of 8 for “"KIRs"”.
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The pattern and functional consequence of Killer Immunoglobulin-like Receptor expression on T cells.
Killer immunoglobulin-like receptors (KIRs) are a family of proteins expressed on human natural killer cells and a subset of T cells. Several inhibitory KIRs have been shown to recognise MHC class I molecules (predominantly HLA-C), with their engagement preventing target cell lysis. The ligand(s) …
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
… on Killer-cell Immunoglobulin-like Receptors (KIRs), which are poorly studied in the field of γδ T cell biology. Because cytomegalovirus (CMV) is known to shape the αβ T cell and NK cell repertoires, I studied peripheral blood (PB) γδ T cells from both CMV-seronegative (CMV-) and …
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Untersuchungen zur immunologische Rolle von HFE, einem HLA Klasse I homologen Gen, das bei der hereditären Hämochromatose Punktmutationen zeigt
… ähnliche Weise über eine <br>Interaktion mit KIRs (Killer cell immunoglobulin-like receptors) oder Lektin-ähnlichen <br>Rezeptoren das Lyseverhalten der NK- und gamma/delta T-Zell-Klone beeinflussen. Mit den <br>durchgeführten Bindungsassays mit KIR-Fc-Fusionsproteinen ließ sich keine Bindung …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
… by killer-cell immunoglobulin-like receptors (KIRs) and activation by the NKp46 natural cytotoxicity receptor, including several related to cellular metabolic pathways. We explored cellular metabolism in the two subsets and found that licensed NK cells are highly glycolytic, and use glycolysis …
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Selezione e processazione di cellule Natural Killer da donatore aploidentico "KIR-ligand" incompatibile per l'immunoterapia adottiva di pazienti con Leucemia Acuta Mieloblastica ad alto rischio
… termed killer immunoglobulin-like receptors (KIRs). In haploidentical T-cell depleted transplantation the donor/recipient KIR mismatch significantly impacts on NK-mediated tumor cell killing, particularly in acute myeloid leukaemia (AML). Thirty-four high risk AML patients entered a phase I-II …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
… and killer-cell immunoglobulin-like receptors (KIRs), and exhibited a gene expression signature of T cell deletion. Surprisingly, ligation of BTLA by its cognate receptor, HVEM, enhanced the survival of CD8<sup>+</sup>BTLA<sup>+</sup> TIL by activating Akt/PKB. Our studies provide a …
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Characterisation of TAPBPR in immune cells
… or killer-cell immunoglobulin-like receptors (KIRs), and only recently deemed as capable of presenting peptides. These studies used soluble HLA-F, when in fact HLA-F naturally has a transmembrane domain. Immunopeptidomic studies performed here, from HLA-F pull downs, revealed it indeed presents …