Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"KINASE-TARGETS"”.
-
A Fragment-Based Drug Discovery Approach for the Development of Selective Inhibitors of Protein Kinase CK2
… application of FBDD in a variety of protein kinase campaigns has successfully led to the identification of novel binding sites and highly efficient chemical ligands. This demonstrates the utility of the FBDD strategy against well-established kinase targets, where selectivity is otherwise …
-
Targeting protein kinases to manage or prevent Alzheimer’s disease
… new treatment strategies and alternative drug targets are currently being heavily researched. One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase …
-
The evolution of protein kinase specificity
… catalysed by a group of enzymes called protein kinases. Through this activity they serve as key regulators of almost all cellular processes. This is achieved at any time by a network of different kinases that are transiently active. The fidelity of cell systems control therefore requires that …
-
Statistical methods to infer kinase activities and kinase-substrate interactions using phosphoproteomic data
The activity of kinases play an important role during cell signalling. They phosphorylate proteins to regulate their interactions, structural conformation, cell location and enzymatic activation. Mass Spectrometry (MS) based phosphorylation studies (i.e. phosphoproteomics) has revolutionized the …
-
Structural analysis of phosphorylation hotspots and kinase target preferences.
… an annotated regulatory role or known regulatory kinase. Devising ways to study the functional importance of phosphosites is therefore a crucial research question. The recognition of target sites by a kinase is thought to be determined by a short contiguous sequence motif around the target …
-
The Role of GRA7, a Component in the ROP18 Protein Complex, in Toxoplasma gondii
… a virulence factor, the serine/threonine kinase ROP18, which plays an important role in the survival of virulent strains of Toxoplasma. In an infected cell ROP18 localizes to the PVM along with many members of the rhoptry (ROP) and dense granule (GRA) family of proteins. On the PVM, ROP18 …