Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"KINASE SIGNALLING"”.
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Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders
… highlighted the importance of aberrant tyrosine kinase signalling in the pathogenesis of these disorders. Cloning of rare chromosomal translocations and point mutation analysis in the MPDs has identified diverse deregulated tyrosine kinase genes, notably PDGFRA, PDGFRB, FGFR1 and JAK2. However …
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Regulation of fungal polar tip extension through NDR kinase signalling
NDR Kinasen spielen eine wichtige Rolle bei der Zelldifferenzierung und morphologischen Prozessen. Über die Regulation von NDR Kinasen und die Vernetzung von NDR Kinase-Signaltransduktionsmodulen ist bisher wenig bekannt. In dem filamentösen Pilz Neurospora crassa ist die NDR Kinase COT1 an der …
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The Regulation of Oncogenic MAP Kinase Signalling by Dual-Specificity MAP Kinase Phosphatases
… observed in human cancers. Dual-specificity MAP kinase phosphatases (DUSPs or MKPs) are important negative regulators of this pathway and could therefore play an important role in modulating the oncogenic potential of signalling. DUSP5 and DUSP6/MKP-3 are ERK-specific MKPs, which are classical …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
… are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of effector …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… tissue growth via ROS-sensitive protein kinases such as the mitogen-activated protein kinase (MAPK). Although there are several different MAPKs, the p38 MAPKs are involved in cardiogenesis and implicated in stimulating myocyte apoptosis, hypertrophy, or even antiapoptotic effects. As …
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The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling
… lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular growth, survival and metabolism. Once activated by environmental …
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The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer
… with HER-2-overexpressing breast cancer. Signalling through alternative receptor tyrosine kinases, such as insulin-like growth factor I receptor (IGF-IR), has been implicated in resistance to Tmab. The main aim of this study was to investigate mechanisms of resistance and in particular the …
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Statistical methods to infer kinase activities and kinase-substrate interactions using phosphoproteomic data
The activity of kinases play an important role during cell signalling. They phosphorylate proteins to regulate their interactions, structural conformation, cell location and enzymatic activation. Mass Spectrometry (MS) based phosphorylation studies (i.e. phosphoproteomics) has revolutionized the …
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Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta
… with different isoforms of the protein kinase CK1 (formerly known as Casein Kinase 1) family via the DUF1669 domain. It is believed that FAM83 proteins may act as subcellular anchors and key regulators of CK1 isoforms. CK1 is thought to be a constitutively active serine/threonine protein …
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Characterising the effects of ACK-mediated phosphorylation on the Class IA PI3-Kinase regulatory isoforms
Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine (Tyr) kinase, was the first effector discovered for the small GTPase Cdc42. ACK is emerging as an important feature of the cancer landscape and thus, is a promising potential target for the treatment of many malignancies. ACK …
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MAP kinase phosphatase-2 in vascular smooth cell muscle function
… occurs involves ligand-induced activation of MAP kinase signalling (Schad et al., 2011). MAP kinases have been noteworthy but troublesome targets in cardiovascular therapeutics; thus exploration of targeting endogenous regulatory dual specificity proteins namely MAP kinase phosphatases has been …
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Structural and functional analysis of a phospho-dependent molecular switch: Rv1827 from Mycobacterium tuberculosis
… modules; however, their precise roles in Ser/Thr kinase pathways and mechanisms of regulation remain unclear. From experiments with Rv1827, an FHA domain–containing protein from Mycobacterium tuberculosis, a complete molecular description of an FHA-mediated Ser/Thr protein kinase signalling …
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
Disruption of protein kinase signalling pathways is often associated with cancer. TheRhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancersand has also been shown to be involved in metastasis and apoptosis. ROCK is inhibited bythe ATP mimic Y27632, which …
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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
… The role of p38 mitogen-activated protein kinase and Rho-kinase signalling was next examined by use of specific antagonists. Blocking p38 mitogen-activated protein kinase and Rho-kinase activity markedly decreased radiation-induced leukocyte and platelet recruitment in the colonic …
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Immunomodulatory effects of LL-37 in the epithelia
… by pretreatment with inhibitors of Src-family kinase signalling and NF-κB translocation. These data suggest that low concentrations of LL-37 may alter epithelial responses to microbes in vivo. Microarray analysis of keratinocyte transcriptional responses after LL-37 treatment suggest that LL-37 …
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Dietary fatty acids modulate inflammatory cytokine production through activation of MAP kinases
… actlvatlon of TLR2 and TLR4 and the downstream signalling pathways This study investigates the effects of a number of PUFA, including conjugated lrnoleic acld (CLA), docosahexaenolc acid @HA) and eicosapentaenolc acld (EPA), on MAP hnase signaling pathways and cytolune production in macrophages …
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The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells
… to regulate MAPK (mitogen activated protein kinase) signalling to elicit pro-inflammatory responses in diseases such as atherosclerosis.1,2 Within the MAPK family, JNK (c-Jun NH2-terminal kinase) is strongly activated by pro-inflammatory cytokines, including tumour necrosis factor-α (TNF-α) …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
… TREM-2 expression through phosphoinositide 3-kinase (PI3K) and PI3K/ p38 MAP kinase signalling pathways respectively. TGF-β1-induced TREM-2 also required extracellular signal-regulated kinase 1/2 post-translationally for protein expression. Interestingly, TREM-2 was required for TGF-β1-induced …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… Tribbles family of serine/threonine pseudokinases (TRIB1-3). Here, we studied murine haematopoiesis after Trib2 ablation under steady state and proliferative stress conditions, including genotoxic and oncogenic stress. At the steady state, we found that TRIB2 loss did not adversely affect …
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Targeting c-met in sonic hedgehog medulloblastomas
… Over the last few years, various tyrosine kinase signalling pathways have been identified to play important roles in medulloblastoma tumorigenesis. Active c-MET kinase has been detected as a marker of SHH-driven MB and several inhibitors provided pre-clinical evidence for an effective …
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