Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3431 for “"KINASE"”.
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Kinase deoxyribozymes
… that is essential for cellular function. Protein kinases, which catalyze phosphorylation, are often motif specific. Engineering these natural kinases to change motif requirements is challenging and often results in decreased substrate specificity. To identify new catalysts for the site-specific …
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Characterisation of calcium/calmodulin-dependent protein kinase kinase 2 in prostate cancer
… novel interactors and functions of the kinase and developed novel inhibitors to improve on STO-609.<br/><br/>We have identified and validated two novel interactors of CaMKK2; Gemin4 and ARCN1. Gemin4 is a member of the SMN complex whose function is in miRNA biogenesis and formation of …
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Regulation of Adenylate Kinase
… mutant enzyme. This protein, called an adenylate kinase-associated protein, co-purified with the wild type and mutant enzymes through several purification steps. A homogeneous preparation of the adenylate kinase-associated protein gave a single band on a sodium dodecyl sulfate-polyacrylamide gel …
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The Regulation of Oncogenic MAP Kinase Signalling by Dual-Specificity MAP Kinase Phosphatases
… observed in human cancers. Dual-specificity MAP kinase phosphatases (DUSPs or MKPs) are important negative regulators of this pathway and could therefore play an important role in modulating the oncogenic potential of signalling. DUSP5 and DUSP6/MKP-3 are ERK-specific MKPs, which are classical …
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Statistical methods to infer kinase activities and kinase-substrate interactions using phosphoproteomic data
The activity of kinases play an important role during cell signalling. They phosphorylate proteins to regulate their interactions, structural conformation, cell location and enzymatic activation. Mass Spectrometry (MS) based phosphorylation studies (i.e. phosphoproteomics) has revolutionized the …
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AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance trained rats
… to examine activity of AMP-activated protein kinase kinase (AMPKK) and AMP-activated protein kinase (AMPK) in muscles from control (C) and endurance trained (T) rats. Rats were trained 5 days/wk, 2 hr/d for 8 wks at a final intensity of 32 m/min up a 15% grade with 30 second sprints at 52 …
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Plasmodium falciparum protein kinase CK2
… in most cellular processes, and protein kinases are considered promising drug targets, comprising as much as 30% of all protein targets under investigation (Cohen, 2002). The divergences between human and plasmodial protein kinases suggest that specific inhibition of the latter is an …
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Proteindesign zur Verbesserung des Nucleosidanaloga-Umsatzes in menschlichen Zellen: Desoxycytidin-Kinase und UMP/CMP-Kinase
… Nucleosid- und Nucleosidmonophosphat-Kinasen spielen eine entscheidende Rolle bei der Aktivierung einer Vielzahl von Nucleosidanaloga, die in der Behandlung von Virus- und Krebserkrankungen eingesetzt werden. In dieser Arbeit wurden Enzyme untersucht, die limitierend für die …
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RAF-1 kinase inhibitor protein-mediated cholecystokinin-2 receptor desensitization and extracellular signal-regulated kinase activation
Raf-1 kinase inhibitor protein (RKIP) is initially known as a suppressor for Raf-1-mediated ERK activation. Moreover, recent findings indicate that RKIP also has a role in G-protein-coupled receptor (GPCR) desensitization. Protein kinase C (PKC)-mediated phosphorylation at Serine 153 (S153) on RKIP …
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Structural and Biochemical Characterisation of the HR1 domains of the Protein Kinase C-related kinase family
… interact with downstream effectors. The protein kinase C-related kinase (PRK) family of serine/threonine kinases consists of three members, PRK1, PRK2 and PRK3, all of which are Rho family effectors. PRKs have three N-terminal Homology Region 1 (HR1) domains, HR1a, HR1b and HR1c. These are …
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SCRIBBLE: A POTENTIAL DUAL KINASE INHIBITOR
Extracellular signal-regulated kinases (ERKs) modulate cellular activities in response to extracellular stimuli and play important biological roles. Thus, perturbed kinase pathways induce pathological conditions, such as tumor development. Rit, a novel member of the Ras family GTPases, activase …
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Casein Kinase I Transduces WNT Signals
… Xenopus embryos. This assay identified a protein kinase, casein kinase I (CKI), as a novel component of the Wnt signaling pathway. We first showed that expression of CKI produces Wnt phenotypes. First, CKI induced completely formed second axes, or Siamese twins, when injected into embryos. Second, …
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Global characterization of oncogenic kinase signaling
… malignancies. Despite major advancements in kinase-targeted cancer therapies, targeting Src has only achieved limited clinical success, thus highlighting the urgent need to better understand the complex signalling network governed by Src and design novel therapeutic strategies. In this …
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Lariat peptide inhibitors of Abl kinase
A majority of kinase inhibitors predominantly occupy the highly conserved adenine-binding pocket located in the kinase catalytic cleft, and therefore the target selectivity of these molecules is a major concern. In order to design highly specific next-generation drugs, it is essential to exploit …
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The evolution of protein kinase specificity
… catalysed by a group of enzymes called protein kinases. Through this activity they serve as key regulators of almost all cellular processes. This is achieved at any time by a network of different kinases that are transiently active. The fidelity of cell systems control therefore requires that …
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Structural Analysis of Domain Swapping in the Protein Kinase: Crystal Structure of Human Ste20 OSR1 Kinase Domain
… constitute a large emerging group of protein kinases including 28 members in human. The Ste20p family has gained remarkable interest, due to the recent finding that it has various intracellular regulatory effects including the regulation of apoptosis and rearrangement of the cytoskeleton …
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