Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"KH2"”.
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ΕΡΕΥΝΑ ΤΗΣ ΠΡΕΣΒΥΑΚΟΥΣΙΑΣ ΣΤΗΝ ΗΠΕΙΡΟ
… IN FREQUENCIES SPECTRUM 0,5,1,2,4 AND 8 KH2 FOR EACH GROUP AND SEX SEPARATELY. STATISTICAL ANALYSIS OF OUR DATA SHOWED THE FOLLOWING RESULTS: 1. OLDER AGES IN BOTH SEXES WERE ACCOMPANIED BY A GREAT DEGREE OF HEARING LOSS AT HIGH FREQUENCIES (2 2. A SEX DIFFERENCE OF ONE DECADE WAS …
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Kh Domains on Brain Polyribosomes: FMRP and Nova in Translational Regulation
… profiles of mice lacking Nova-1 or FMRP. The KH2 and RGG box RNA-binding domains of FMRP bind specific RNA motifs that form kissing complex and G-quartet structures, respectively. We find that the association of FMRP with polyribosomes in both mouse brain and human neuroblastoma cells is …
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Die Regulation der prokaryontischen Transkription auf molekularer Ebene
… RNA-Bindungsregion wird durch die S1-, KH1- und KH2-Domänen aufgebaut. Die beiden carboxyterminalen acidic repeats AR1 und AR2 erfüllen jeweils unterschiedliche Aufgaben, die bisher nur zum Teil aufgeklärt sind und im Rahmen dieser Arbeit untersucht werden. Eine weitere Rolle spielt NusA bei der …
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Fragile X Mental Retardation Protein Induces Synapse Loss Through Acute Postsynaptic Translational Regulation
… of synapse number. An intact K homology 2 (KH2) RNA-binding domain and dephosphorylation of FMRP at S500 are required for the effects of FMRP on synapse number, indicating that FMRP-dependent translation of mRNA targets of FMRP leads to synapse loss. Furthermore, I demonstrate novel …
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Identification of Loss of Specific FMRP-RNA Interactions as a Cause of Fragile X Syndrome
… the developing synapse. Therefore, loss of FMRP KH2 domain specific RNA binding and proper regulation of RNA metabolism contributes to the synaptic dysfunction underlying the pathogenesis of cognitive and behavioral deficits observed in Fragile X Syndrome.</p>