Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"KH domain"”.
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Structure and Function of KH Domain in DDX43 and DDX53 Cancer Antigen Helicases
… RNA helicase family, and contain a K-homology (KH) domain in their N-terminal regions and a helicase core domain in their C-terminal regions. The KH domain was first characterized in the human heterogeneous nuclear ribonucleoprotein K (hnRNP K). The typical function of KH domain is to bind …
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Functional Analysis of the 15 KH Domain Human Nucleic Acid Binding Protein, Vigilin
… 15 related, but nonidentical K homology (KH) nucleic acid binding domains. Despite its high level of conservation among species, the precise function(s) of vigilin remain unclear. Vigilin was identified in our lab as the trans-acting factor which binds to the 3' untranslated region of …
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Nucleoid-Associated Proteins of Streptomyces coelicolor: Discovery and Functions
… regulator. It was found to comprise a KH domain with an N-terminal extension and formed oligomers of 10 - 12 subunits in solution. The mutant phenotypes of both S. coelicolor paralogs of HU (HupA and HupS) were examined and showed opposite effects on growth, spore formation and …
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Post-transcriptional coordination by an RNA-binding protein
… I describe a role for the RNA-binding protein Khdl in regulating these two responses to environmental stress through its mRNA targets. I identified the RNA targets of Khdl using in vivo crosslinking and immunoprecipitation (CLIP), combined with deep sequencing. This produced a high-resolution …
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Structural and Functional Studies of ASCC1 in DNA and RNA Alkylation Damage Response
… uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with splicing, transcriptional regulation, and translational control) and two-histidine phosphodiesterase (PDE) (associated with hydrolysis of cyclic nucleotide phosphate bonds). Germline …
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Towards Understanding Helicase and Chaperone Activities in the RNA Degradosome
… structure of a portion of the RNase E C-terminal domain that recruits enolase and helicase, and the association between Hfq, ChiX and the RNase E C-terminus. The thesis also explored structural details regarding the small domain of RNase E involved in both RNA binding and oligomerisation and its …