Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"KDR"”.
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Modeling of interactions between vascular endothelial growth factor family members and their receptors KDR and Flt-1
… Responses to VEGF are mediated by Flt-1 and KDR, two cell-surface receptors selectively expressed by vascular endothelial cells. A secreted form of Flt-1 (sFlt1) retains high affinity for VEGF and can compete for VEGF binding, thereby inhibiting angiogenic responses. In this study, a …
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To investigate whether VEGF and KDR polymorphisms are associated with chronic Achilles tendinopathy and self-reported measurements of tendon pain
… receptor referred to as kinase domain receptor (KDR) are key regulators of neovascularisation and can be associated with pain. Common DNA sequence variants within the VEGFA and KDR genes have previously been associated with musculoskeletal soft tissue injuries, including AT. The primary aim of …
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Cyclic stretch-mediated release of vascular endothelial growth factor by vascular smooth muscle cells : a role in improved vascular graft patency
… cells, the effect of cyclic strain on the KDR-mediated endothelial response to locally-released VEGF was also investigated. Low passage number bovine aortic SMC and EC were plated on collagen-coated elastomer plates and subjected to 10% repetitive strain at 1 Hz. The mRNA expression of VEGF …
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Detection And Characterization of Insecticide Resistance Mechanisms in Culex Tarsalis
… vectors that possess genetic mutations (denoted kdr and ace-1 ) and/or enhanced detoxifying enzymes (oxidases, esterases, and glutathione-s-transferases) that confer insecticide resistance. Culex tarsalis, a primary vector for West Nile virus among other arboviruses in Northern California, is a …
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Angiogenetische Faktoren bei Psoriasis, Ulcus cruris venosum und Dermatoliposklerose
… einer gesteigerten Reaktivität für Flt-1, KDR und Tie-2 im Vergleich zur Normalhaut. In der RT- PCR zeigte sich eine deutliche Zunahme der Transkripte für Tie-2, Ang-1 und Ang-2 in psoriatischen Biopsien vergleichend zur Normalhaut. Wir vermuten, dass die psoriatische Hyperproliferation zu …
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Sengketa waris Islam pasca amandemen pasal 49-50 Undang-Undang no 7 tahun 1989: Analisis yuridis terhadap putusan PN Kab Kediri perkara no. 83/Pdt.G/2009
… Putusan Perkara No No 83/Pdt.G/2009/PN/Kab Kdr dengan ditinjau menurut hukum Acara Peradilan Agama. Metode penelitian ini, menggunakan penelitian normatif yang mengkaji tentang asas-asas hukum dengan menggunakan pendekatan yuridis normatif analitis. Sedangkan dalam teknik pengumpulan data, …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… in mRNA expression of VEGF and its receptors KDR, sFlt-1 and Flt-1 occurs in pathological angiogenesis, i.e. metastatic tumorigenesis. We hypothesize that the ratio of sFlt-1:Flt-1 mRNA will be altered in the presence of solid tumors. The objective of this study was to evaluate the expression …
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STUDIES ON INSECTICIDE RESISTANCE IN TUTA ABSOLUTA (MEYRICK), WITH SPECIAL EMPHASIS ON CHARACTERISATION OF TWO TARGET SITE MECHANISMS
… to pyrethroids, termed knockdown resistance (kdr), has been shown to arise through alterations (point mutations) in the para-type sodium channel protein leading to reduced sensitivity of the insect nervous system to the pyrethroids. Mutations in the Ace gene have also been reported to cause …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
… with a new risk gene, Kinase insert domain (KDR), encoding vascular endothelial growth factor receptor 2 (VGFR2), and a strong association with a new candidate gene, COL6A5. While BMPR2, TBX4, EIF2AK4, ACVRL1 and AQP1 showed the highest association (PP≥0.99), I also confirmed significant …
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Whole genome sequencing approach to identifying genetic risk factors underlying anterior cruciate ligament injuries in a twin family study
… (rs699947 C/A rs1570360 G/A, rs2010963 G/C) and KDR (rs2071559 A/G, rs1870377 T/A) genes (Sweden CON: 116 ACL: 95; Poland CON: 149 ACL: 127 and Australia CON: 83 ACL: 342). Additionally, in the ACAN (rs2351491 C/T, rs1042631 T/C, rs1516797 T/G), DCN (rs516115 T/C) and BGN (rs1126499 C/T, …
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Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
… trained, H3K27me3 decreased. Angiogenic gene Kdr mRNA expression decreased after 9 weeks of endurance training. Overall, exercise protocols affect the histone modifications and histone modifiers in the skeletal muscle.
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A Novel Population of Cardiovascular Progenitors Persist in Neonates as Mesendodermal Cells
… isolated from the heart itself express ISL1, KDR, and MESP1, and are capable of differentiating into all major cardiac lineages. The earlier developmental stage at which endogenous CPCs reside may be associated with enhanced multipotency and differentiation capacity. A clonal population of …
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Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin
… or both, cells expressing both VEGF receptor-2 (KDR) and the insulin receptor were immunoprecipitated for total Akt and PLC-γ. Isolates from cells stimulated with both ligands demonstrated activation of PLC-γ and Akt that was less than additive over fifteen minutes. Conversely, cells pretreated …
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Role of the Intron 13 Polypyrimidine Tract in Soluble Flt-1 Expression
… migration via interactions with its receptors, KDR and Flt-1. A secreted form of Flt-1 (sFlt-1), derived from alternatively-spliced RNA, can inhibit actions of VEGF in vivo. It has been suggested that alterations in sFlt-1 expression could significantly change the angiogenic VEGF activity. This …
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The role of vascular endothelial growth factor isoforms in early follicle development
… signaling through the VEGFA receptors, FLT1 and KDR. Ovaries treated with VEGFR-TKI had vascular development reduced by 94%. In addition, treated ovaries had more primordial follicles, fewer early primary, transitional, and secondary follicles, and greater total follicle numbers compared with …
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Einfluss von Mistelextrakt, Selen, Kavir-Protein und Ascorbinsäure auf die Genexpression angiogener Wachstumsfaktoren und das Sprossverhalten humaner Granulosazellen
… Growth Factor VEGF A sowie dessen Rezeptor KDR exprimieren. Dies eröffnet die Möglichkeit eines autokrinen Loops bei GC. <br>(1) Die Stimulation mit Mistelextrakt führte bei den GC zu einer signifikanten Verminderung der VEGF A-Expression. Trotzdem beeinflusste es das Sproutverhalten der GC …
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In vivo studies of suspected mechanisms of DDT-resistance in Blattella germanica (L.)
… responsible for resistance to knockdown (Kdr) or paralysis by DDT in houseflies. This mechanism may alter the site of action of DDT and result in a reduced binding capacity of resistant insect nerve tissue for the DDT molecule as compared to susceptible insect nerve tissue.
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Advanced Studies in Veterinary Anatomy: Angiogenesis in Caprine Reproductive Organs of Non-Pregnant and Pregnant Normal and Swainsonine-Treated Does
… and kinase-insert domain-containing receptor, KDR) was measured using real-time quantitative PCR. Targets were detected in all studied tissues; however, levels of expression differed according to the stage of pregnancy. Expression of VEGF and its receptor mRNAs increased with advancing …
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Resident angiogenic mesenchymal stem cells from multiorgan donor thoracic aortas
… cultured cells showed an increased expression of KDR and eNOS, down-regulation of the CD133 transcript, vWF expression as documented by flow cytometry, immunofluorescence, qPCR and TEM. Moreover, matrigel assay revealed that VEGF induced cells were able to form capillary-like structures within 6 …
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Characterization of the expression of angiogenic factors in the feline placenta during development and in feline cutaneous squamous cell carcinoma
… to the protein that transmits its signal (KDR) was elevated in CSCC, suggestive of an altered signaling relationship. This finding supports our hypothesis and is consistent with human SCC studies. Our results encourage further studies on angiogenic factor variants in feline CSCC.
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