Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"KDEL"”.
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Charakterisierung eines Proteinkomplexes in Säugerzellen, der am Transport zwischen Membrankompartimenten beteiligt ist.
… Fehlgeleitete Proteine aus dem ER, die ein KDEL-Motiv am C-Terminus tragen, werden im Golgi durch den KDEL-Rezeptor Erd2 gebunden und zum ER zurücksortiert. Der Rezeptor wandert durch COPI-abhängigen Transport zwischen dem Golgi und dem ER. FRET-Messungen ergaben in dieser Arbeit, dass …
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… MHCI heterodimers, thus bridging MHCI to the KDEL receptor: KDELR) rescue pathway. Unlike other ER-resident immune evasion proteins, CPXV203 did not display distinct allelic preferences, but instead proved to be an extremely promiscuous MHCI-binder: murine and primate, Ia and Ib). Similar to …
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Proteinkonjugationen durch Kupfer-abhängige Formylglycin-generierende Enzyme zur Generierung von Antikörper-Wirkstoff-Konjugaten
… of the C-terminal amino acid sequences KDEL or PGEL successfully increased both, the ER retention of hFGE and the FGly conversion rate of in situ antibody production in CHO cells, resulting in an FGly content of up to 91.7%. Using an extensive model protein library for the establishment …
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The characterisation of a recombinant cytosolic shuttle based on ricin toxin
… a C-terminal 6His, HA and Lys, Asp, Glu, Leu (KDEL) motif) (clone 189), were found to be 2h pre-induction incubation, induction (with 0.25mM IPTG) and a 4h post-induction incubation, cultured at 37oC. Upon further characterisation, recombinant RTBC (rRTBC) was found not to be lectinic, unlike …