Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"KCNQ2"”.
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The Diversity of FHF-mediated Ion Channel Regulation
… potassium channel regulator, which binds to KCNQ2 and regulates both localization and function. FGF14 is also capable of serving as a “bridge” between VGSCs and KCNQ2 thus implicating it as a broad organizer of the AIS. FGF13, on the other hand is involved in a new form of neuronal plasticity …
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Explorando los canales de potasio KCNQ : una perspectiva en trastornos del neurodesarrollo y cardíacos
… en la regulación de la excitabilidad neuronal (Kcnq2-5), del estrés oxidativo (Sod1 y Sod2) y la memoria (Chrna7, Chrna4 y Chrnb2). En ratones KD, se encontró un aumento de la sociabilidad, y un cambio en la memoria de reconocimiento a corto plazo. En animales adultos, la expresión de Sod1 y …
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Charakterisierung von KCNQ-Kaliumkanälen und ihren Beta-Untereinheiten
… einer Punktmutation im Spannungssensor von KCNQ2. Hierbei wurde untersucht, warum diese Mutation nicht nur zur Neugeborenen-Epilepsie führte, sondern in den betroffenen Patienten zusätzlich Myokymie verursachte. Der dritte Teil bestand aus Patch clamp Messungen an Mausmodellen für die …
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The investigation of pathophysiological mechanisms underlying KV7-related epilepsy and neurodevelopmental delay
… Neuronal Kv7 channels composed of Kv7.2/KCNQ2 and Kv7.3/KCNQ3 subunits are enriched at the axonal plasma membrane where their voltage-dependent potassium currents suppress neuronal excitability. Close to 400 variants in Kv7.2 subunit cause Benign Familial Neonatal Epilepsy (BFNE), …
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Intrinsic Neuronal Plasticity of Kiss1 Neurons in Mice around Puberty
… of female mice. Scn2a (the gene for NaV1.2), Kcnq2 (the gene for KV7.2) and Lrrc55 gene (the gene for BKγ3 subunits) were higher in 3-week pre-pubertal mice than in post-pubertal mice, while Hcn1 expression was lower in 3-week pre-pubertal mice. The implications of these changes for neuronal …